[Immune reactivity in patients with myasthenia gravis following removal of the thymus gland].
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Biomedical subjects
Publications and source records attributed to P György.
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The results of heigh tibia osteotomy performed between 1970 and 1975 in 20 cases in the material of the Orthopaedic Department of the "Semmelweis" University Medical School, Budapest, are reported. In 13 cases good--in 6 cases satisfactory results have been obtained. In 1 case the surgical intervention was of no effect. With regard to the explicit pain-relieving effect the operation is recommended by the authors in the treatment of knee arthrosis.
The effect of age on vitamin B6 metabolism was studied in 617 community-dwelling subjects, ages 18 to 90. These are, for the most part, clinically healthy, educated men whose intake of nutrients is not limited by economic factors. Plasma pyridoxal phosphate (PLP) was used as the primary criterion of vitamin B6 status. About one-third of the subjects were taking supplementary vitamins on their own initiative. The amount of pyridoxine-HCl varied from 0.1 to 105 mg/day. The average plasma PLP of the men not taking a supplement (N = 414) was 12.3 +/-0.3 ng/ml, with 25% of the values below 7.5 ng/ml and 7% below 5 ng/ml. There was a statistically significant decrease in plasma PLP with age of 0.9 ng/ml per decade. For those taking a supplement, the average plasma PLP was 20.5 +/- 1.0 ng/ml, with only 8% of the values below 7.5 ng/ml and none below 5 ng/ml. Glutamic-oxaloacetic transaminase activity in plasma (PGOT) and erythrocytes (EGOT) was determined on all subjects. The ratio of EGOT with in vitro stimulation by PLP to EGOT actual (alpha-EGOT) was also studied. These studies provide the most extensive normative data on vitamin B6 status available on men in the adult years of life.
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Patients with rheumatoid arthritis were found to have low plasma pyridoxal phosphate. Treatment with 50-150 mg/day of pyridoxine hydrochloride for 3 months caused a rise in pyridoxal phosphate in most cases to more than 3 times pretreatment levels. There was, however, no improvement in the clinical aspects of rheumatoid arthritis.
The nowadays accepted principles of the treament of open leg fractures are discussed. The open character of the lesion multiplies the possibilities of complications. In the present paper the complications of the bone recovery are not dealt with, only the complications observed in the soft parts and the possibilities of their treatment are analysed by the authors. According to the severity of the soft parts complications free transplantation of semi-thick skin, pedicle flap plasty, double-end graft plasty, crossed flap grafting, as well as the primary and secondary variations of these methods are used by the authors. The satisfactory results obtained with these methods even in spite of the complications are pointed out by the authors.
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