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P H Edelstein

Publications and source records attributed to P H Edelstein.

116 records · Page 7Linked to original sources
PubMed1979

Four serogroups of Legionnaires' disease bacteria defined by direct immunofluorescence.

Thirty-five strains of Legionnaires' disease bacteria were shown to belong in four distinct serologic groups on the basis of findings obtained with direct fluorescent antibody testing. Thirty of the strains were placed in group 1, three in group 2, one in group 3, and one in group 4. Immunoelectrophoretic studies showed both unique and common antigens among the representative strains of the four serogroups.

Antigens, Bacterial↗
PubMed1978

Isolation of a new serotype of legionnaires' disease bacterium.

A new serotype of the legionnaires' disease bacterium has been isolated. The strain appears to be identical with the Philadelphia strain except for the cell-wall antigens as tested by a direct fluorescent antibody technique. Demonstration of a new serotype brings into question the diagnostic specificity of currently used reference strains.

Bacteria↗
PubMed1978

Legionnaires' disease in renal-transplant recipients.

Legionnaires' disease is reported in five renal-transplant recipients. All had febrile respiratory illnesses with pulmonary infiltrates and one died. The diagnosis was made on clinical features and by indirect fluorescent antibody titres. Symptoms started after maximum immunosuppressive therapy.

Adult↗
PubMed1978

Infections caused by Klebsiella ozaenae: a changing disease spectrum.

A total of 64 isolates of Klebsiella ozaenae were recovered from 36 patients during a 40-month period. Over 7,500 isolates of K. pneumoniae were isolated during the same time period. Before this decade, K. ozaenae was considered to be only a colonizer of the nasopharynx or a putative cause of ozena (atrophic rhinitis). K. ozaenae was recovered most frequently from sputum in mixed culture but was associated with infection in 12 patients (2 with bacteremia, 3 with urinary tract infection, 1 with soft tissue infection, and 6 with mucopurulent nasal discharge). The spectrum of disease caused by this organism is more extensive than has been appreciated previously.

Adult↗
PubMedDate not supplied

In vitro activity of lomefloxacin (NY-198 or SC 47111), ciprofloxacin, and erythromycin against 100 clinical Legionella strains.

Agar dilution minimum inhibitory concentrations (MICs) of lomefloxacin (LO), ciprofloxacin (CI), and erythromycin (ER) were determined for 100 clinical isolates of Legionella using buffered charcoal yeast extract medium supplemented with alpha-ketoglutarate (BCYEa). The Legionella strains tested included 84 L. pneumophila, 2 L. micdadei, 6 L. dumoffii, 4 L. longbeachae, and one each of L. bozemanii, L. hackeliae, L. wadsworthii, and L. maceachernii. Geometric mean MICs microgram/ml were 0.56 for LO, 0.50 for CI, and 0.25 for ER. Ninety percent MICs were 1.0 for LO and CI, and 0.5 for ER. All Legionella strains except one (L. hackeliae) were inhibited by 1.0 microgram/ml of LO or CI; this strain had an Er MIC of 1.0 microgram/ml and was inhibited by 2.0 micrograms/ml of LO or CI. Control strains of Eschershia coli and Staphylococcus aureus were also tested on both BCYEa and Mueller-Hinton agar (MHA) to determine BCYEa-mediated inhibition of the antimicrobials. All three antimicrobials were inactivated in varying degrees by BCYEa. BCYEa:MHA MICs of the S. aureus control strain were 4:1 for LO and ER, and greater than 4:1 for CI. BCYEa: MHA MICs of the E. coli control strain were 4:1 for LO and CI, and unmeasurable for ER. Both LO and CI have good in vitro activity against legionella, probably greater than that measured in this study because of antimicrobial inactivation by BCYEa. Since LO is concentrated by phagocytic cells, like ER and CI, it is likely that it will be effective in the treatment of Legionnaires' disease.

Anti-Infective Agents↗