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Biomedical subjects

P H Kidner

Publications and source records attributed to P H Kidner.

36 records · Page 2Linked to original sources
PubMed1976

Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction.

Oral disopyramide given prophylactically following myocardial infarction has been compared with placebo in a double-blind trial using continuous-tape monoriting of the electocardiogram. It caused a significant reduction in the incidence of ventricular arrhythmias and of the various degrees of heart-block. There was a significant reduction of reinfarction during hospital stay in patients who had received disopyramide. Disopyramide appears to be a safe and effective oral therapy in the prevention of potentially serious arrhythmias following myocardial infarction.

Administration, Oral↗
PubMed1971

Myocardial infarction and deep-vein thrombosis.

In a study of 52 patients admitted into the coronary intensive care unit the incidence of deep-vein thrombosis was measured with the (125)I-fibrinogen test. Of these patients 31 were eventually confirmed to be suffering from acute myocardial infarction. This preliminary study showed that in patients with a confirmed infarct who were not treated with anticoagulants the incidence of deep-vein thrombosis was 38% and in those treated it was 5.5%. In patients who were "severely ill" from whatever the cause there was a high incidence of deep-vein thrombosis (68%).

Anticoagulants↗
PubMedDate not supplied

Assessment of the effect of coronary artery bypass grafting on left ventricular performance by Doppler measurement of the aortic blood velocity during exercise.

The effect of coronary artery bypass grafting (CABG) on left ventricular (LV) function is studied noninvasively in 30 male patients with a mean age o 55.4 years using the continuous-wave Doppler technique of transcutaneous aortovelography (TAV). With a transducer applied in the suprasternal notch the main-stream aortic blood velocity recordings were obtained before and at maximum-tolerated supine exercise both prior to, and six weeks after, CABG. From the TAV recordings the stroke distance (Sd: or the systolic velocity integral which is a measure of the stroke volume) and minute distance (Md: or the measure of cardiac output) were derived as well as the percentage changes in these parameters with exercise (% delta Sd and % delta Md successively). Whereas no significant change following CABG was observed in the resting values for Sd, a significant improvement in the maximal exercise values for Sd and Md as well as the % delta Sd and % delta Md was noticed after CABG (p less than 0.001). Prior to CABG the % delta Sd (an indicator of left ventricular function) was significantly lower in 13 patients with a history of an old myocardial infarction (MI). The % delta Sd in these 13 patients was also significantly lower than that in the 17 patients without a history of MI though the improvement in the % delta Sd following CABG was similar in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenergic beta-Antagonists↗
PubMedDate not supplied

Non-invasive assessment of left ventricular function in coronary artery disease by Doppler stress testing.

Left ventricular (LV) function in 62 patients presenting with chest pain typical of angina was studied non-invasively at rest and at maximum-tolerated supine exercise using the continuous-wave Doppler technique of transcutaneous aorto-velography (TAV). The signals were analysed to derive peak velocity (Vp), systolic velocity integral [an index of stroke volume or stroke distance (Sd)], and minute distance (Md; index of cardiac output = Sd X heart rate). Comparison was made with results obtained from 66 normal volunteers. The percentage change in stroke distance with exercise (% delta Sd) was significantly related to the resting ejection fraction (EF) calculated from left ventriculography (r = 0.84), and was below 6% (lowest value observed in normal volunteers) in all of the 23 patients with coronary artery disease (CAD) whose EF was below 60%. No significant difference was observed in the % delta Sd between normal individuals and the 12 patients presenting with chest pain but who had normal coronary arteriograms. However, the % delta Vp, delta % Sd and % delta Md in the 50 patients with CAD were significantly lower than the normal individuals and the 12 patients with normal coronary arteriograms. Lower TAV measurements were observed with exercise, rather than at rest, with increasing number of coronary arteries with significant stenoses and the presence of history of myocardial infarction (linear trend p less than 0.003). These results suggest that Doppler recording of aortic blood velocity with exercise is a clinically useful non-invasive technique for studying LV performance in patients with CAD.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗