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P H Lamont

Publications and source records attributed to P H Lamont.

18 recordsLinked to original sources
PubMed1978

Serological evidence of continuing infection of swine in Great Britain with an influenza A virus (H3N2).

Serum samples collected from swine and cattle in Great Britain at various times between July 1971 and July 1977 were examined by haemagglutination-inhibition or single radial haemolysis methods for evidence of infection with influenza A (H3N2) viruses. A small proportion of swine sera collected in each year reacted in the tests but there was no evidence of infection in cattle. The significance of the findings is discussed, with particular reference to the seasonal fluctuations in the prevalence of antibody in swine observed during the period of the study, and their possible relevance to influenzal events in the human population. None of the sera tested had antibody to swine influenza strains (HSw1N1).

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PubMed1976

The eradication of Arizona 7: 1, 7, 8 from a turkey breeding flock.

Day old turkey poults (the F generation) were imported from the USA into the UK and in 1968 young turkey poults of one hatch (F1 generation) showed clinical signs and lesions of arizona infection and serotype 7: 1, 7, 8 was isolated from stock of both generations. After the F3 generation, the flock was dispersed to several large breeders but there seems to have been no evidence of arizona infection in the subsequent five generations of progeny.

Animals↗
PubMed1972

Studies on relationships between human and porcine influenza. 1. Serological evidence of infection in swine in Great Britain with an influenza A virus antigenically like human Hong Kong-68 virus.

Serological evidence of infection of swine in Great Britain with an influenza A virus closely related to the human A/Hong Kong/68 (H3N2) variant was detected by a variety of serological tests. The Hong Kong/68 virus was first detected in man in Great Britain in August 1968 and was prevalent in the winters of 1968-69 and 1969-70. There was no evidence that swine had been infected with a Hong Kong/68-like virus before the appearance of the virus in man. The detection of virus-neutralizing antibody and high titres of neuraminidase-inhibiting antibody for Hong Kong/68 virus, and the production of precipitin lines corresponding to influenza A ribonucleoprotein and haemagglutinin and neuraminidase antigens of Hong Kong virus in immunodiffusion tests indicated that the swine sera contained antibody specific for the Hong Kong/68 virus. Evidence suggested that the infection of swine occurred in the early months of 1970. Clinical influenza among swine in Great Britain was not reported during the study period and there was no serological evidence of infection with "classical" swine influenzavirus strains.

Animals↗
PubMed1972

Studies on relationships between human and porcine influenza. 2. Immunological comparisons of human A-Hong Kong-68 virus with influenza A viruses of porcine origin.

Antigenic comparisons were made between the human A/Hong Kong/68 (H3N2) virus and a collection of influenza A viruses of swine origin. Haemagglutination-inhibition and neuraminidase-inhibition tests were used in addition to immunoprecipitin tests with monospecific antisera prepared against purified haemagglutinin and neuraminidase preparations. The antigenic relationships revealed by the studies are summarized as follows: (1) swine/Taiwan/7310/70 virus contained envelope antigens that were antigenically indistinguishable from those of A/Hong Kong/68 virus, (2) "classical" strains of swine influenzavirus related to A/swine/Iowa/15/30 (Hsw1N1) isolated between 1930 and 1967 contained neuraminidase that was antigenically distinct from that of A/Hong Kong/68 virus but related to that of human A0 and A1 viruses, and (3) the haemagglutinins of certain strains of "classical" influenza A virus appeared to show a minor antigenic relationship with the haemagglutinin of A/Hong Kong/68 virus. Immunoprecipitin tests suggested that this relationship was confined to only one of the two antigenic components of the haemagglutinin subunit. The antigenic relationships are discussed in respect of possible epidemiological relationships between human and swine influenza A viruses. It is proposed that the swine/Taiwan isolates be designated A/swine/Taiwan/70 (H3N2), indicating their antigenic identity with the human A/Hong Kong/1/68 virus.

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PubMed1970

Characteristics of a virus isolated from a feline fibrosarcoma.

A virus was isolated from a radioresistant feline fibrosarcoma. It induced multi-nucleated giant-cell formation and lysis in a cell line derived from a canine fibro-sarcoma, which was used to characterize the virus. End-point titrations in these cells required 28 days. The virus was sensitive to ether and heat and was destroyed at pH 3. Replication was not inhibited by 5-bromodeoxyuridine. Electron microscopy revealed assembly by a budding process from the plasma membrane of infected cells. The average diameter of the virion was 106 nm. Intracisternal particles with an average diameter of 45 nm were present within infected cells. In two instances secondary monolayers of feline renal cells underwent morphological transformation after inoculation of the virus. The two strains of transformed cells are now in continuous culture and do not yield infectious virus.

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