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Biomedical subjects

P H Langner

Publications and source records attributed to P H Langner.

7 recordsLinked to original sources
PubMed1986

Plasma cortisol and norepinephrine concentrations in castrated male pigs maintained in pairs in outdoor pens and in a confinement finishing house: assessment of stress.

A catheter-backpack system was developed for repeated blood collection in pigs. Castrated male pigs (n = 12) were maintained in pairs in outdoor pens and later in a slotted-floor confinement finishing house. Blood collection required no restraint and appeared to be stress free. Serum cortisol concentration was unchanged by mode of maintenance. However, diurnal variation of cortisol was more pronounced when pigs were housed. A significant decrease (P less than 0.05) in serum norepinephrine concentration occurred during the housing period.

Animals↗
PubMed1985

A nonrestrictive method for maintaining grouped swine for blood sampling applicable to physiologic assessment of stress.

Studies of the stress response in swine require repeated blood sampling to determine diurnal variations of measured parameters. Most of these methods require elaborate artificial habitats such as metabolism crates and/or physical restraint for venipuncture. In either case, the aversive nature of the sampling procedure induces activation of the hypothalamic-hypophyseal-adrenal cortical axis. The development of a nonaversive procedure for repeated blood sampling of swine is described in this paper. The pigs were unrestrained and maintained in groups in a variety of habitats.

Animal Husbandry↗
PubMed1981

Glomerular basement membrane changes in aging nondiabetic and diabetic guinea pigs.

Glomerular hyperplasia and thickening of the glomerular basement membrane increase with age in humans and animals. This glomerulopathy can be enhanced by hyperglycemic conditions such as diabetes mellitus. When diabetic guinea pigs were examined by fluorescent microscopy, deposits of a substance similar to immunoglobulin G (IgG) were seen. Comparison with nondiabetic age-matched control animals suggest that glomerulopathy is related to aging, and can be further enhanced by hyperglycemia.

Aging↗