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P H MAURER

Publications and source records attributed to P H MAURER.

At least 19 recordsLinked to original sources
PubMed1965

ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). 13. IMMUNOLOGICAL STUDIES WITH SYNTHETIC POLYMERS CONTAINING ONLY D- OR D- AND L-ALPHA-AMINO ACIDS.

It has been demonstrated that polymers consisting solely of D-alpha-amino acids are not immunogenic in rabbits, guinea pigs, man, and mouse, whereas the same polymers of L-alpha-amino acids are very effective antigens. This has been attributed to the importance of metabolizability of a polymer in contributing to its immunogenicity. In the glu-lys-ala series of polymers, the immunogenicity of a polymer of 2 L-amino acids and a D-amino acid appears to be governed by the immunogenicity of the 2 L-amino acids. However, some of the specificity may be directed towards configurations containing the D-amino acid. It has been noted that injections of rabbits with polymers of D-amino acids has resulted in a reduced response against the isomeric L polymer.

Amino Acids↗
PubMed1964

ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). XII. IMMUNOLOGICAL STUDIES WITH A NEW GROUP OF SYNTHETIC COPOLYMERS.

A new group of synthetic random polymers of alpha-L-amino acids has been studied for immunogenicity. With the glutamic acid and alanine copolymers, those consisting of almost equimolar amounts of the two (G(60)A(40) and G(40)A(60)) were effective antigens in rabbits whereas those with higher glutamic acid contents (G(75)A(25), G(90)A(10)) were poor antigens. The substitution of alanine by valine or leucine (G(75)V(25) and G(80)Leu(20)) produced copolymers which were poor antigens in rabbits but effective in guinea pigs. L(70)A(30), although capable of "non-specifically" precipitating serum proteins, was shown not to be antigenic in either rabbits or guinea pigs. The introduction of alanine into glutamic acid and lysine polymers (GLA series) enhanced the immunogenicity of the terpolymers, i.e., GLA30 > GLA20 > GLA10 > GL. The mechanism by which this may be accomplished is discussed as possibly being related to the reduction of the interactions between glutamyl and lysyl residues which allows the carboxyl groups to act as strong immunogenic determinants.

Alanine↗
PubMed1963

STUDIES ON ARTIFICIAL ANTIGENS. II. THE ANTIGENICITY IN GUINEA PIGS OF ARSANILIC ACID CONJUGATES OF COPOLYMERS OF D- OR L-ALPHA-AMINO ACIDS.

An effort was made to immunize guinea pigs with arsanilic acid conjugates of copolymers of D- and L-alpha-amino acids; ASD-GAT and ASL-GAT. An immune response was observed only in the case of ASL-GAT. Antibodies specific for the arsanilic acid hapten were produced which could also react with ASD-GAT or ASGPA. These findings indicate that the proper metabolism of the antigen may be essential to the induction of the immune response.

Alanine↗
PubMed1963

Antigenicity of polypeptides: immunological unresponsiveness to copolymers of gamma-amino acids.

Immunological tolerance toward three synthetic random copolymers of the alpha-amino acids, glutamic, lysine, alanine, and tyrosine, was produced by a single injection of the polymers into newborn rabbits. The tolerant state could be extended by an additional intravenous injection of antigen. Repeated injections of the polymer in adjuvant mixture could "break" the tolerant state.

Adjuvants, Immunologic↗
PubMed1962

Antigenicity of polypeptides (poly alpha amino acids). VII. Studies in humans.

It has been shown that the polymers GLA5, GLT, GLA40, and GLAT are antigenic in human beings. Both immediate skin reactions and delayed (cellular) reactions were observed. The antibody produced reacted well in the precipitin reaction, agglutinated antigen coated tanned sheep cells, was less effective in inducing PCA reactions, and failed to sensitize guinea pigs for passive systemic anaphylaxis. The immediate skin reactivity appeared not to be related to the P-K antibody. The delayed reaction was histologically distinct from the immediate reaction and consisted of perivascular lymphocytic infiltration in contrast to the predominantly polymorphonuclear cells in the latter reaction. The antigenic response against the polymers resembled that observed with proteins. From cross-reactions it appears that the response is heterogeneous in the sense that not all individuals react against the same groupings in the complex polymers.

Amino Acids↗
PubMed1961

Immunologic studies with ethylene oxide-treated human serum.

The antigenicity of an ethylene oxide-treated human serum in humans has been studied. The immune response to the material had many of the characteristics of a delayed cellular skin reaction. Even after repeated immunizations by intradermal skin testing over a period of 1(1/2) years, no detectable antibody could be found in the sera. The antigenicity has been shown to be associated with drastic alteration of the homologous serum proteins as evidenced by (a) the formation of new proteins, and (b) the poor cross-reactions of the modified serum proteins with antisera against normal human serum albumin and normal human gamma globulin. The delayed hypersensitivity was transferable to normal recipients by either viable or killed leukocytes. The implications of these findings have been discussed with respect to the problem of sterilization of sera, the tuberculin reaction, and autoimmune phenomena.

Antiemetics↗