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Biomedical subjects

P Hée

Publications and source records attributed to P Hée.

16 recordsLinked to original sources
PubMed1999

The diagnosis of appendicitis during pregnancy and maternal and fetal outcome after appendectomy.

OBJECTIVE: A review of the literature reveals contradictive conclusions regarding appendicitis during pregnancy due to the few patients included in previous reports. METHODS: From 1980 to 1985, the Danish National Patient Registry identified the patients having the WHO codes Y60 (pregnancy), 54000 (acute appendicitis) and the operation code 43 000 (appendectomy). Each patient's file was reviewed by the authors. RESULTS: The ratio of appendicitis (n = 58) to appendectomy (n = 117) was 50%. The appendicitis group was significantly older (26.2 years) than the normal appendix group (23.8 years). Second trimester had the highest incidence of appendicitis, perforated appendicitis and normal appendix. No effect of tocolytic agents could be demonstrated. No maternal mortality. Obstetrical complications were few and appeared only in the group having a normal appendix and first after discharge. CONCLUSIONS: Pregnant women suspected of having appendicitis should be evaluated as non-pregnant women. Use of tocolytic agents is a matter of choice. Obstetrical complications are few and not related to the surgical trauma.

Adolescent↗
PubMed1999

Compliance to estrogen treatment one to three years after hysterectomy and bilateral salpingooophorectomy. The cohort's lifestyle, knowledge of ERT, benefits etc.

BACKGROUND: To determine compliance to Estrogen Replacement Therapy (ERT) initiated at discharge from a gynecological department in perimenopausal women having had hysterectomy (hyst.) and bilateral salpingooophorectomy (BSO) for benign disease. To investigate this cohort's knowledge and attitude to ERT, lifestyle issues, sources of information etc. METHODS: A questionnaire was sent to the patients 1-3 years after discharge (April 1993 to December 1994). RESULTS: Eighty-eight patients were identified and returned the questionnaire. Seventy-nine were included in the statistics. Eighty-nine percent were still compliant to treatment. Forty-two percent received their information about ERT from newspapers/magazines and 17%) from GPs. Ninety percent knew that ERT prevented osteoporosis, 33% knew about the positive effect on cardiovascular disease (CVD). Sixty-nine percent believed that ERT increased the risk of breast cancer and 74% anticipated an increase in quality of life. CONCLUSION: Even though not offered any follow-up visits, 89% of this cohort was still on ERT 1-3 years after hyst. and BSO. This high rate of compliance might be due to initiation of treatment during hospitalization with the information given at discharge combined with a low rate of side effects of ERT. The women's primary source of information was newspapers/ magazines, and they were aware of the benefits of ERT on climacteric symptoms and osteoporosis but not so much the benefits on CVD. The major concerns were the risk of breast cancer and weight gain.

Adult↗
PubMed1998

Fertility and long-term complications four to nine years after appendectomy during pregnancy.

BACKGROUND: The purpose of this study was to determine the long-term outcome after an appendectomy during pregnancy, especially focusing on fertility. METHODS: The Danish National Registry of Patients identified 117 pregnant women who had had an appendectomy during the period 1980 to 1985. One hundred-and-one of these women answered a questionnaire designed to focus on long-term complications, including infertility, during a 4 to 9 year period after the appendectomy. More than a 2-year attempt to conceive was defined as infertility. RESULTS: Of the 101 women 15 with a normal appendix had a new intraperitoneal operation due to different indications. Three of these women had intraperitoneal adhesions. In one patient, adhesions were located on the Fallopian Tube but the location did not influence fertility. Five of the 101 women complained of infertility as defined; all had a normal appendix and none had intraperitoneal surgery during the observation period. Two of these five women conceived later during the observation period; one had confounding female and male infertility factors and two were not examined. CONCLUSIONS: Appendectomy during pregnancy of a normal, inflamed or perforated appendix does not seem to cause clinically significant intraperitoneal adhesions or infertility later in life.

Adult↗
PubMed1992

Histologic examination of the rat central nervous system after intrathecal administration of human beta-endorphin.

The objective of this study was to evaluate histologically the toxicity of human beta-endorphin on the rat central nervous system after intrathecal administration. Animals received a single injection of 5 micrograms (n = 9) or 50 micrograms (n = 10) on each of four consecutive days, while others received 50 micrograms (n = 8) as a single dose. The control groups received either physiologic saline (n = 10) during each of four consecutive days or had sham operations (n = 4). Tests for nociception (tail-flick latency), motor function, and reflexes (righting reflex, eye-blink reflex, and inclined plane) were performed 5, 15, 30, 60, and 120 min after injection. Both dosages produced a dose-dependent impact on these parameters. In the 50-micrograms group, there were no significant differences in analgesia between the first and the fourth doses injected. The 50-micrograms dose produced catalepsy in some animals. All changes returned to baseline within 24 h. One animal in the 50-micrograms group developed hind limb paralysis after a single injection. Histologic sections from brain, brain stem, and spinal cord were prepared. No changes in histology were found except for that in the paretic animal, which had anoxic changes in the hippocampus and other cortical areas. Human beta-endorphin produced no neurotoxicity. The effect on nociception, reflexes, and motor function confirmed the results of previous studies.

Animals↗
PubMed1987

Intrathecal administration of morphine for the relief of pains in labour and estimation of maternal and fetal plasma concentration of morphine.

Thirteen healthy women in active labour received an intrathecal injection of morphine 1.0 mg. Eighty-five percent (11 patients) experienced acceptable or good pain relief. Analgesia set in 15-45 min after injection and reached a maximum after 15-120 min and lasted until delivery. Eighty-five percent (11 patients) of the patients developed mild side-effects i.e., pruritus, nausea and emesis. The intrathecal injection of morphine did not adversely affect the condition of the infant. Venous blood samples from the patients and umbilical cords for estimation of plasma morphine showed extremely low concentrations. No patients experienced any discomfort during the injection of morphine. These results indicate that morphine 1.0 mg administered intrathecally decreases labour pains to an acceptable level.

Anesthesia, Obstetrical↗
PubMed1987

Primary carcinoma of the fallopian tube.

The records of 50 patients with primary carcinoma of the fallopian tube referred to postoperative radiotherapy at the Radium Centre of the Finsen Institute, Copenhagen, were reviewed. The most common symptoms were postmenopausal bleeding, vaginal watery discharge and abdominal pain. In 86% of the patients a palpable pelvic tumor was found at preoperative gynecologic examination. Disease was localized to the pelvis (stage I and stage II) in nearly all patients (92%). Ten patients were given radiotherapy as vaginal radium twice combined with deep X-ray to the pelvis, and 38 patients were given radiotherapy as high-voltage irradiation to the pelvis only. The overall survival at 5 years was 50.9%. Still, the role of radiotherapy in the control of this rare disease remains to be established. To obtain a better prognosis for this disease, international cooperative prospective studies are proposed.

Actuarial Analysis↗