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P HAGEN

Publications and source records attributed to P HAGEN.

At least 19 recordsLinked to original sources
PubMed1962

Observations on the substrate specificity of DOPA decarboxylase from ox adrenal medulla, human phaeochromocytoma and human argentaffinoma.

The substrate specificity of the dopa decarboxylases of ox adrenal medulla, human phaeochromocytoma and human argentaffinoma have been studied. The enzymes from all three tissues decarboxylated dopa, metatyrosine, orthotyrosine and 5-hydroxytryptophan. Dopa was decarboxylated most rapidly and 5-hydroxytryptophan least rapidly by the enzyme from all three tissues. Competition experiments indicate that all four substrates are decarboxylated by the one enzyme. Attempts to demonstrate decarboxylation of [C(14)]-tyrosine, [C(14)]-tryptophan or [C(14)]-histidine by these enzyme preparations were unsuccessful.

5-Hydroxytryptophan↗
PubMed1961

Effect of reserpine on growth and sexual development of chickens.

One-month-old male chickens were given injections of 1 mg, 2 mg and 4 mg/kg of reserpine. The injections were repeated at weekly intervals for three months. The chickens receiving reserpine grew at half the rate of untreated control chickens and failed to grow combs. At 4 months of age the testes of reserpine-treated chickens were only about one-tenth the weight of the testes of the control chickens and histologically they showed extreme hypoplasia of the seminiferous tubules. Two large doses of reserpine one month apart could cause atrophy of the testes of adult roosters.

Animals↗