Biomedical subjects

P Haakonsen

Publications and source records attributed to P Haakonsen.

3 recordsLinked to original sources

PubMed1998

[Epididymitis in infants--a possibility].

Usually, acute scrotum in infants is due to torsion, but there are reasons to believe that primary inflammation occurs more often than supposed. Urethrovasal reflux is the primary mechanism, and it is often associated with urogenital anomalies among infants and dysfunctional voiding among young boys. Colour Doppler ultrasound, scintigraphy and surgical exploration are the tools for differentiating epididymitis from torsion. We present a six months' old child with epididymitis, who was investigated because of suspected torsion. The investigations showed bacteruria, but no anomalies.

Diagnosis, Differential↗

PubMed1998

Identification of a melanocyte growth-inhibiting tripeptide and determination of its structure.

The function and proliferation of melanocyte cell populations are influenced by a wide range of hormones and growth factors. Local cell renewal after sudden melanocyte loss appears to be regulated according to a negative feedback principle, however. In accordance with this assumption, we have examined growth-inhibitory activity in water extracts of cultured non-transformed melanocytes and melanoma cells (B16 cells). The extracts were fractionated by gel filtration on Sephadex G-25 and Fractogel MG 2000, by ion-exchange chromatography on DEAE-cellulose and Dowex 50 and by reverse-phase high-performance liquid chromatography on Bondesil and Partisil columns. Two peptides were isolated with the structures pyroGlu-Phe-GlyNH2 and pyroGlu-Cys-GlyNH2 as revealed by mass spectrometry, peptide sequencing and amino acid analysis. The two peptides were synthesized and tested for the ability to inhibit the growth of melanocyte cultures. Only pyroGlu-Phe-GlyNH2 was inhibitory. The dose-response curve was bell-shaped with maximum inhibition around 10(-15) M. The melanocyte tripeptide thus appears to be a new member of a group of N-substituted growth-regulating oligopeptides found in other tissues.

Animals↗

PubMed1995

[What nobody thought possible--a "demobilization chain" gone astray. Foreign body in the urinary bladder--a current differential diagnosis].

Intravesical foreign bodies should be considered in cases of unexplainable lower urinary tract symptoms or recurrent urinary tract infections with therapy-resistant microbes like Proteus mirabilis and Pseudomonas. Usually these conditions are due to accidents in genitourinary surgery or instrumentation, but in our case occurred as a complication to an erotic procedure. This paper describes a case with a so-called "dimme-lenke", i.e. a chain used to count down days until demobilization from compulsory military service for Norwegian recruits, found in the bladder of a 13-year-old boy. A knot at the end of the chain made endoscopic removal impossible and it had to be removed by cystotomy.

Adolescent↗