Biomedical subjects

P Hagel

Publications and source records attributed to P Hagel.

9 recordsLinked to original sources

PubMed1986

Chromium, nickel, copper, zinc, arsenic, selenium, cadmium, mercury and lead in Dutch fishery products 1977-1984.

Within the framework of a monitoring programme, carried out by order of the Dutch Ministry of Agriculture and Fisheries, fishery products from Dutch coastal waters, estuaries and inland waters were investigated for the presence of trace elements. In this report the results for the period 1977-1984 are presented. The investigated fishery products included sole, cod, plaice, herring, eel, pike-perch, shrimp and mussel, in which the elements chromium, nickel, copper, zinc, arsenic, selenium, cadmium, mercury and lead were determined. The results are compared with data from the literature and with the trace element levels usually found in other animal products. The daily intake of trace elements in The Netherlands through the consumption of Dutch fishery products is calculated.

Animals↗

PubMed1985

Genotoxicity testing of arsenobetaine, the predominant form of arsenic in marine fishery products.

Marine fishery products may contain high levels of arsenic, mainly in the form of organic arsenic compounds. Arsenobetaine has been identified as the predominant form occurring in marine fishery products. The potential initiating and promoting capacities of this compound were therefore investigated in vitro. In the Salmonella typhimurium assay, no mutagenicity was observed in strains TA97, TA98 and TA100 without activation or after addition of a liver-enzyme fraction or gut-flora extract. The compound was also negative in the forward mutation assay of the HGPRT gene and in the test for sister chromatid exchanges in V79 Chinese hamster cells. No inhibition of metabolic co-operation between V79 Chinese hamster cells was observed at arsenobetaine concentrations up to 10 mg/ml. In addition, arsenobetaine had no synergistic or antagonistic effects on the action of the positive controls benzo[a]pyrene and tetradecanoylphorbol-13-acetate.

4-Nitroquinoline-1-oxide↗

PubMed1978