Biomedical subjects

P Hassell

Publications and source records attributed to P Hassell.

4 recordsLinked to original sources

PubMed1999

Radial sclerosing lesions of the breast: mammographic and pathologic correlation.

OBJECTIVE: The purpose of this study was to define the mammographic appearance of 96 pathologically proven radial sclerosing lesions (RSLs) and to determine the frequency of association with malignancy in and around the lesions. METHODS: Ninety-three patients with 96 RSLs were identified from the pathology files of the BC Cancer Agency, and the reasons for biopsy were obtained. All preoperative mammograms were reviewed, and the RSLs were categorized as classic (typical), non-classic (atypical), or incidental. The histopathologic results were retrospectively examined for atypia, ductal carcinoma in situ (DCIS) and invasive carcinoma. RESULTS: In 67 of the 96 biopsies, the RSL was the primary mammographic abnormality that led to biopsy. In this group, 17 cases (25.4%) contained atypia, 17 (25.4%) DCIS, and 4 (6%) invasive carcinoma. Nineteen of these RSLs presented as mass-like opacities that mimicked carcinoma. No single mammographic feature consistently predicted premalignant or malignant lesions. In the remaining 29 patients, biopsy was carried out because of pleomorphic calcifications or masses, and RSLs were found incidentally in specimens. These specimens included 4 cases (13.8%) of atypia, and 1 case (3.4%) of DCIS. CONCLUSION: Of the 67 mammographically detected RSLs, only 48 (71.6%) had a typical mammographic appearance. We found a significant amount of atypia (25.4%) and malignancy (25.4% DCIS and 6% invasive carcinoma) in mammographically detected RSLs. Because of the lack of predictable radiological features, adequate open surgical biopsy is recommended for all focal abnormalities in which a RSL is a possible diagnosis.

Adult↗

PubMed1994

Ovarian cancer: computed tomography findings.

Ovarian cancer is one of the most common malignant lesions in women. Radiologists are often called upon to interpret and report computed tomography (CT) findings for staging such lesions and for evaluating the patients' response to therapy. A variety of manifestations of this disease can be seen with CT, each of which can have a spectrum of appearances. These manifestations include ascites, peritoneal seeding, and visceral and nodal metastasis. A selection of situations commonly encountered in women with ovarian cancer, as well as several unusual ones, are depicted in this pictorial essay.

Female↗

PubMed1982

Gastrointestinal manifestations of neurofibromatosis in children: a report of two cases.

Two patients with von Recklinghausen's disease (neurofibromatosis) involving the gastrointestinal tract are described. The manifestations of the disease were very different in each patient. In the first, the similarity of the diffuse abdominal form of plexiform neurofibromatosis to childhood sarcoma is emphasized. In the second, megacolon with a transition zone in the lower sigmoid colon producing a pseudo-Hirschsprung's appearance was present.

Adolescent↗

PubMed1982

Bowel opacification using "Telebrix 38" for CT scanning.

Prior to abdominal and pelvic computed tomographic (CT) scans in children, bowel opacification was performed with dilute sodium ioxitalamate, meglumine and sodium diatrizoate, or barium sulfate. CT scans of 112 patients using one of these contrast agents were reviewed to compare "image quality." We have obtained the best organ and tissue definition when dilute sodium ioxitalamate was utilized to opacify the gastrointestinal tract.

Adolescent↗