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Biomedical subjects

P Hecketsweiler

Publications and source records attributed to P Hecketsweiler.

At least 37 records · Page 2Linked to original sources
PubMed1981

Transient pulmonary impairment during attacks of Crohn's disease.

Lung function was studied in 10 patients with Crohn's disease during and after an attack of the disease. Pulmonary volumes and lung transfer factor were not impaired but functional residual capacity was greater during the attack than during remission; it was also greater than in normal subjects. FRC values and disease activity decreased concomitantly during remission as well as finger clubbing. The etiology of this impairment was unknown.

Adult↗
PubMed1979

[Gastrointestinal haemorrhage related to alcoholic cirrhosis. Prognostical influence of digestive lavage (author's transl)].

During gastrointestinal bleeding associated with cirrhosis, the presence of blood within the lumen of the gut may cause or favorise the onset of hepatic coma. Digestive lavage by rapid intragastric infusion of an isotonic solution based upon mannitol may reduce the mortality due to hepatic coma. The value of this method was studied retrospectively by comparison of two series of haemorrhagic complications: Group I-1971-1976: 224 haemorrhagic complications treated in the usual manner; Group II-1976-1977: 127 haemorrhagic complications treated in accordance with a protocol which included digestive lavage. The results indicate the prognostic significance of certain clinical signs (ascites, jaundice, shock), and also made it possible to determine the cause of death and to demonstrate a reduction in mortality in the group treated by digestive lavage (p < 0.02), concerning only deaths as a result of hepatic coma (p < 0.01) above all in forms with a poor initial prognosis with shock or decompensation with jaundice and ascites.

Adult↗
PubMed1979

Oral BCG vaccine in Crohn's disease.

In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn's disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking the control preparation (P greater than 0.1). No significant benefit from oral BCG treatment has been demonstrated.

Adolescent↗
PubMed1979

Absorption of elemental and complex nutritional solutions during a continuous jejunal perfusion in man.

The jejunal absorption of either an elemental solution (amino acids, glucose and glucose oligosaccharides), or of nonelemental diet (chicken meat, egg-yolk power, soya flour, glucose, saccharose, maltose and dextrin maltose, corn and wheat oils) were compared in 25 healthy subjects by the technique of intestinal perfusion with a three-lumen tube. The test solutions were perfused just beyond the ligament of Treitz. The samples were collected 35, 70 and 105 cm below the infusion point. In a small segment of jejunum, the absorption increased the nutritional imbalance of the element diet 1 m below the infusion point, the flow rate in the lumen was similar for the two solutions and higher than the initial flow rate; the absorption, in terms of calories, is similar for the two solutions.

Adolescent↗
PubMed1979

Elastic properties of the rectal wall in normal adults and in the patients with ulcerative colitis.

The elastic properties of the rectal wall have been studied in 16 normal adults (group I) and in 24 patients with ulcerative colitis, during a nonactive (13 cases, group II) or an active period (11 cases, group III). The rectal intraluminal pressures after accommodation to the distension were significantly higher in group III than in groups I and II. These pressures were not related to distending volumes in groups I and II but were correlated with the distending volumes in group III. The rectal elasticity coefficient was significantly greater in group III than in the other two groups. There was an inverse correlation between the rectal elasticity coefficient and the rectal area. These results suggest a loss of the rectal distensibility in active colitis.

Adolescent↗
PubMed1978

Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects.

Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection of secretions at 35 and 70 cm from the infusion point. The results show that a crushed food homogenate has a greater stimulative effect on pancreatic enzyme secretion than the elemental solutions and that this can be directly related to its greater nitrogen content. The osmolality of the infused solutions does not appear to be important. The relative merits of the solutions tested and total parental nutrition in reducing pancreatic enzyme secretion are discussed.

Adolescent↗
PubMed1977

Rheumatic symptoms in Crohn's disease and the HLA system.

The study of the distribution of the HLA phenotypes among 55 patients suffering from Crohn's disease did not show any significant difference compared to a control population. On the other hand, the same study limited to patients suffering both from Crohn's disease and peripheral articular manifestations showed a significant increase in the frequency of the HLA BW17.

Crohn Disease↗