[Heterologous insemination with frozen semen and ovulation time].
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Biomedical subjects
Publications and source records attributed to P Helm.
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In order to disclose differences between users and non-users of oral contraceptives (OC), 620 women aged 15-54 were invited to participate in an in depth interview about sexual, contraceptive, and reproductive life events. Of the 585 women who participated, 459 were consecutive gynecological in- or outpatients, and 126 were selected from visitors in general practice. Data was analysed by multivariate test statistics. After correction for present age and social class, the duration of use of OC (DOC) among women 15-34 years of age correlated negatively to age at menarche and coital debut and positively to number of sexual partners, oral-genital sexual practice, and number of pelvic inflammatory diseases. Among women over 35, DOC was positively associated only to cigarette smoking. No correlation was found to coital frequency (whether earlier, present or during pregnancy or menstruation), number of births and abortions, or to social classification. In epidemiological research on benefits and risks of oral contraceptives, confounding influence of one or more variables is of crucial importance. The present findings point at sexual and life-style habits as potential confounders in the study of OC and associated diseases.
Pregnancy outcomes in 22 consecutively operated women with Müllerian anomalies are described. In 16 women the indication for metroplasty was two or more spontaneous abortions and/or premature deliveries. The frequency of successful pregnancies increased from 5% before to 76% after operation. In 6 women metroplasty was performed on account of infertility. It is argued that infertility rarely constitutes an indication for metroplasty, and only when concurrent causes of infertility have been excluded. Several of the postoperative pregnancies and deliveries presented serious complications. Cesarean section is therefore recommended in some deliveries after metroplasty.
A 50-year-old women was admitted on suspicion of abdominal tumor. Clinical examination and ultrasonography revealed a living fetus of 24.2 weeks' gestational age. Amniocentesis revealed trisomy 18 (Edwards' syndrome). At 34 weeks the fetus died spontaneously, and by cesarean section a stillborn boy of 770 g was delivered. The risk of pregnancy in women after the age of 45 is emphasized.
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Functional ability and social dependence were investigated by personal interview of 107 lower limb amputees surviving 1-5 years postoperatively. Among eight independent variables studied by multiple regression analysis, increased age was associated unfavorably with physical ability and social dependence. Independence from social provisions preoperatively showed favorable relationships with functional capacity and postoperative dependence. Above-knee or bilateral amputation and postoperative pain were associated with reduced functional ability, but not with social dependence. No significant association was found with cause of operation or sex of the amputees. The importance of proper prosthetic fitting and pain control is emphasized.
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Mean age at menarche was estimated by the status quo method in the same region of Denmark in 1965-66 and 1982-83 in 983 and 1 591 girls, respectively. During that period menarcheal age decreased by 4 months from 13.40 to 13.03 years, subsequent to a similar decrease from 1949-50 (2) to 1965-66. Comparison with recent data from the other Nordic countries, except Norway, indicates that age at menarche is now close to 13 years, and a halt in the trend towards earlier menarche is not evident.
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The earliest Danish study of mean age at menarche by Ravn (Fenger 1850) is analysed with special reference to age recordings and their subsequent groupings into age-classes. Uncertainties of interpretation of the age designations are discussed, and it is argued that, in all probability, mean age at menarche was 17 years in the samples of Danish women born around 1820, rather than below 16 years as believed previously.
The purpose of this study was to evaluate the incidence of neuropathy in a consecutive cohort of patients with major burn injuries and investigate the clinical correlates for both mononeuropathy and generalized peripheral polyneuropathy. Of 572 patients examined, 64 (11%) patients had clinical evidence of mononeuropathy or peripheral neuropathy or both. Associations of mononeuropathy and peripheral neuropathy with potential risk factors were identified using logistic regression analyses. Electrical cause (odds ratio [OR] = 4.1022, P < .01), history of alcohol abuse (OR = 2.2893, P <.05), and number of days in intensive care (OR = 1.0457, P < .001) were significantly associated with mononeuropathy. The number of days in intensive care (OR = 1.0740, P < .001) and patient age (OR = 1.0543, P < .01) were significantly associated with peripheral neuropathy. This study demonstrates that neuropathy is a common complication of severe burn injury in patients who are older, critically ill, have an electrical cause, or history of alcohol abuse.
To determine 1) change over time in Quality of Life (QOL) and 2) functional, community reentry, and psychosocial predictors of QOL, data were prospectively collected from adults with major burn injury 2 months after hospital discharge (n = 110) and 6 (n = 97) and 12 (n = 69) months after injury. The dependent QOL variable was the Burn Specific Health Scale (BSHS) and the predictor variables were Brief Symptom Inventory, Functional Assessment Screening Questionnaire, Functional Independence Measure, Pain Analog Scale, and Community Integration Questionnaire. BSHS global scores were unchanged across the measurement periods. Stepwise multiple-regression analyses resulted in statistically significant multiple Rs of.79 at 2 months,.81 at 6 months, and.76 at 12 months. Variables predicting more favorable BSHS global score were less emotional distress and pain at 2 months, less emotional distress and pain and better community reentry at 6 months, and less emotional distress and better community reentry at 12 months.
The purpose of this study was to assess the effectiveness of serial casting of burn contractures that were resistant to traditional methods of treatment such as paraffin therapy, massage, exercise, and splinting. Serial casting was used to increase the range of motion in 35 joints in 15 patients with burns. A mean increase of 54% was achieved. Casting provided immediate results with minimal complications and was accepted well by patients. Casts were easy to apply and effective even with noncompliant patients. They also delayed or eliminated the need for surgical correction.