Adaptations to training in the racing camel.
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Adaptation, Physiological↗
Biomedical subjects
P Henkel
Publications and source records attributed to P Henkel.
[Possibilities for optimization of radiotherapy of esophageal carcinoma through measurement of the oncoradiogenic enzyme peak of glucosephosphate isomerase].
In 20 patients with oesophageal carcinoma blood samples were taken after the first irradiation and the activity of the glycolytic enzyme glucose-6-phosphate isomerase was measured. In all patients there occur GPI peaks at reproducible times. The height of the enzyme peak occurring 15.5 to 19.5 hours p.irr. expresses a significant dependence on tumour size and irradiation dose. The frequency of a late occurring enzyme peak depends on the appearance of regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view and the meaning of such enzyme peaks for the optimization of radiation therapy is pointed out.
Adult↗
[Possibilities for optimizing radiotherapy of cancers of the ENT area by measuring oncoradiogenic enzyme peaks of glucose-6-phosphate isomerase].
Blood samples were taken from 39 patients with head and neck carcinomas after the initial irradiation, and the activity of the glycolytic enzyme glucose-6-phosphate isomerase (GPI) was measured. All patients showed GPI peaks at reproducible times. The height of the enzyme peak occurring 15.5-19.5 h after irradiation, was significantly correlated with tumour size and histological tumour differentiation. A late enzyme peak was associated with regional lymph node metastases. Possible sources of the enzyme peaks are discussed from a radiobiological point of view, and the value of such enzyme peaks for the optimization of radiation therapy is pointed out.
Adult↗
[Continuous hemodilution using a low-molecular hydroxyethyl starch solution. Pilot studies in patients with acute cerebral ischemia].
The intention of this study was to examine whether it is possible to induce an acute and long-time hemodilution by a 6% Hydroxyethyl Starch solution (HES 40). This study was investigated in 30 patients with acute cerebral ischemia. Primarily a isovolemic infusion of HES 40 was made in order to reduce the hematocrit nearly 40%. Secondly, a hypervolemic infusion of 1,000 ml/24 h followed during 4 days. Then 500 ml/24 h for the next 6 days, respectively. The neurological staging was estimated by special scores, the rheological effects by changing of values of hematocrit, hemoglobin, plasma viscosity, number of blood cells, concentration of total plasma protein and fibrinogen concentration. It can be stated that HES 40 induced a significant acute and long time decrease of blood parameters (4 weeks later). After this time, the symptoms of cerebral ischemia could not be observed in 54% of cases and were reduced significantly in 31 percent. 2 patients had transitory ischemic attacks and 4 patients died during therapy. These results demonstrate that this new therapy (long time hemodilution with HES 40) is ingenious for patients with acute cerebral ischemia, because HES 40 has lower undesired effects than HES 200.
Adult↗
[Optimizing radiotherapy for carcinomas of the tongue and floor of the mouth. Measurement of oncoradiogenic enzyme peaks of GPI].
After a first irradiation with 2 and 5 Gy blood samples were collected at 30 minutes' intervals for 24 hours in 19 tongue cancer patients to assess the activity of the glycosis enzyme glucose-6-phosphate isomerase (GPI) and the creatine kinase (CK). In all patients the GPI activity exhibited peaks at reproducible points in time. Observed for the very first time, this GPI peak had a height at 15 to 18 hours following radiation that correlated with the tumor volume and the irradiation dose. We refer to it as the oncoradiogenic enzyme peak. The frequency of the appearance of a late enzyme peak is significantly related to the presence of regional lymph node metastases. The radiobiological considerations regarding the potential causes for such post-irradiation increases in enzyme activity are discussed. The impact of demonstrating oncoradiogenic GPI peaks for optimizing radiotherapy is outlined.
Adult↗