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Biomedical subjects

P Heroux

Publications and source records attributed to P Heroux.

2 recordsLinked to original sources
PubMed1988

High-voltage electrical injury: acute pathophysiology.

A reproducible high-voltage electrical injury model was established in the primate using a new approach to energy administration, measurement instrumentation, and data acquisition. Patterns of current repartition and temperature generation were examined in 24 primates. The predominant current load was carried in muscle, which is the tissue group occupying the largest cross-sectional area. Highest temperature values observed were in muscles of small cross-sectional diameter and in tissues of high inherent resistance. Surgeons should be aware of the principles and the pattern of current distribution when performing early debridement and/or definitive coverage procedures.

Animals↗
PubMed1988

High-voltage electrical injury: chronic wound evolution.

A chronic electrical burn model employing documentary and diagnostic techniques was designed in the primate for investigating wound evolution up to 10 days after injury. A standardized 40-kJ, 3500-V, 4.2-A, 2.5-s bilateral, symmetrical upper extremity electrical injury was performed. Gross observation studies documented tissue injury extending more proximally on the deep surfaces of individual muscles and between muscle layers. Specific regions, or "choke" points, in the forearm exist in which decreased cross-sectional areas and highly resistant tissue composition resulted in increased heat production and more severe tissue damage. Muscle injury was analyzed using light microscopy, revealing patchy cellular necrosis intermixed with viable cells. Digital subtraction angiography demonstrated segmental narrowing and "pruning" of large vascular trunks with a significant decrease in nutrient vessels in affected areas. Ulnar nerve conduction studies showed loss of conduction proximal to the cubital fossa with no recovery. Although characteristic patterns of injury were documented in skin, muscle, vessels, and nerves, no experimental evidence was found for progressive necrosis.

Angiography↗