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Biomedical subjects

P Herrlich

Publications and source records attributed to P Herrlich.

At least 217 records · Page 12Linked to original sources
PubMed1972

Negative control of protein synthesis after infection with bacteriophage T7.

T7 phage induces two negative control mechanisms of protein synthesis: (a) Host-gene expression is repressed by a "T7 repressor," and (b) early T7 protein synthesis is inhibited by a late phage protein.(a) The repressor for host enzyme synthesis is an early T7 protein. Its gene is none of the known early genes; it is located promotor-proximal to gene 1. The repressor function of this protein can be demonstrated by DNA-dependent enzyme synthesis in vitro.(b) Expression of early phage gene is depressed by a late phage protein or by T7 RNA polymerase. Control takes place on the level of transcription.

Bacterial Proteins↗
PubMed1971

Control of gene function in bacteriophage Tr. 3. Preventing the shutoff of early enzyme synthesis.

Synthesis of early T4 protein, which is normally shut off at 10 min after infection, continues until lysis when host cells have been preinfected with T3 sam(+). In host cells preinfected with T3 sam(-), synthesis of early enzymes is shut off as normal. Thus, S-adenosylmethionine is required for the turnoff of early T4 functions (at least when host cells have been preinfected with T3).

Aminohydrolases↗
PubMed1970

T3 and T7 bacteriophage deoxyribonucleic acid-directed enzyme synthesis in vitro.

The T3 phage enzymes S-adenosyl methionine cleaving enzyme and lysozyme and the T7 lysozyme were synthesized in a deoxyribonucleic acid (DNA)-dependent, cell-free system derived from uninfected Escherichia coli. The data presented suggest that these enzymes are encoded in that portion of the DNA which is transcribed early after infection.

Carbon Isotopes↗