[Conduction anesthesia by cold block. A new possibility in the treatment of chronic pain].
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Anesthesia, Conduction↗
Biomedical subjects
P Hiedl
Publications and source records attributed to P Hiedl.
[Changes of the pain threshold induced by analgetic drugs (author's transl)].
In two groups (i.v. and p.o. application) of 6 healthy subjects we tested the changes of the individual pain threshold induced by Flupirtine, Pentazocin and placebo under double blind conditions. The experimental pain was caused by radiant heat for isolated C-fiber-stimulation. The results of p.o. application showed an average increase of the pain threshold of +1,27 degrees C by Flupirtine, +0,81 by Pentazocin, and a slight decrease of -0,68 degrees C by placebo. The figures under i.v. application were +2,04 degrees C for Flupirtine, +1,01 degrees C for Pentazocin and +0,16 degrees C for placebo.
Administration, Oral↗
Local analgesia by percutaneous electrical stimulation of sensory nerves.
Experimental C-fiber pain caused by radiant heat was applied to the skin area supplied by the left sural nerve of 20 subjects. Percutaneous electrical stimulation (PNS) was performed on the left sural nerve, the left superficial peroneal nerve and the right superficial radial nerve. Stimulation frequencies were: 3, 50, 100, 300, 500 and 1000 Hz. The analgesia resulting at the different stimulation sites was recorded according to a preset scale of estimation. Without considering the influence of the different frequencies, the best analgesic effects were reached if noxious heating and PNS were both performed on the left sural nerve; the anatomical conditions prevented us from distinguishing between the effects of possible peripheral blockade or spinal modification of pain. PNS of the superficial peroneal nerve seems to indicate spinal, possibly polysegmental, interactions between C-fiber pain and electrical stimulation of thick myelinated fibers. However, long loop effects may also play a part in local analgesia as demonstrated by PNS of the right radial nerve.
Adult↗
TNS-evoked long loop effects.
Local analgesia can be produced by transcutaneous electrical stimulation of peripheral nerves. This is used in the treatment of chronic pain states. Its clinical effectiveness depends on two points; namely (1) the stimulation has to be perceptible, and (2) paresthesias elicited by TNS must be localized in the area of pain. To verify this in healthy subjects we produced an experimental pain by radiant heating of the skin and tested the analgesic effect of TNS. TNS stimuli parameters (duration, amplitude and frequency) were determined so that double blind conditions were given. Stimulation with small rectangular pulses showed the best analgesic effect especially at a stimulation rate of 100 Hz. The stimulation of various nerves showed that most of the analgesic effects depend on spinal level mechanisms but probably long loop effects are involved.
Analgesia↗
[The fixed lumbar lordosis due to slipped disks].
The fixed lumbar lordosis is represented by a group of characteristic symptomes; they specifically happen to the LWS of adolescents which are in a specific pathogenic situation. The cause of the fixed lumbar lordosis is almost a slipped discus. The case of an adolescent is presented, who had two operations because of twice slipped discus in one year.
Adolescent↗