Beclomethasone and osteocalcin.
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Beclomethasone↗
Biomedical subjects
P Holt
Publications and source records attributed to P Holt.
[Indicators of coronary risks--attitude, knowledge and behavior. An interview study among 917 men and women aged 25-44 years].
The purpose of this study was to clarify whether there was any agreement between knowledge about coronary risk factors, attitudes to individual prevention of coronary heart disease and preventive health behaviour. In particular the differences between males and females were examined. A total of 749 persons ranging in age between 25 and 44 (that is 82% of a random group of 917 persons) were interviewed in this cross sectional study. Physical inactivity, smoking and fat consumption were used as behaviour related risk factors. Generally, young adult Danes had a poor knowledge and poor health behaviour related to coronary heart disease in spite of their positive attitudes towards prevention. The study indicated that neither attitudes nor knowledge were correlated to preventive health behaviour. Women had better health behaviour patterns than men despite the same amount of knowledge and attitudes. In the above mentioned connexions, men showed positive correlation while no correlation existed for women.
Adult↗
Immunosuppressive effects of Fusarium moniliforme corn cultures in chickens.
In the present study, the toxic and immunosuppressive effects of three isolates of Fusarium moniliforme (MRC 826, MRC 1069, and RRC 408) in male White Leghorn chickens were investigated. Chickens were fed diets containing .5, 5.0, or 25% of F. moniliforme corn cultures for 6 wk. About 30% of the chickens fed RRC 408 had leg weakness. Relative weights of bursae of Fabricius were lower in birds fed all doses of MRC 826. Birds fed 5.0 or 25% MRC 1069 had lower relative spleen weights. Thymus weights were lower in birds fed .5 and 5.0% RRC 408, but not in those fed 25%. Immunosuppressive effects were determined by measuring serum levels of primary and secondary agglutinin responses to SRBC and Brucella abortus. Birds fed 5.0 or 25% MRC 826 were immunosuppressed, as shown by low antibody titers to B. abortus in both the primary and secondary responses. Isolate MRC 1069 caused a decrease in secondary response to SRBC at 25% and B. abortus at the 5.0 and 25% of culture material. The RRC 408 isolated reduced the secondary response to SRBC at all doses and response to B. abortus at 5.0 and 25% of culture material. These results appear to be the first report that feed contaminated with F. moniliforme can produce deficiencies in the immune system of chickens.
Animals↗
Acceleration of conduction within an accessory pathway with propafenone.
We describe a case of dangerous acceleration of conduction through an accessory pathway produced by the Class IC agent propafenone during routine electrophysiological study of a patient with Wolff-Parkinson-White syndrome. This pro-arrhythmic effect has not previously been described with this drug. Propafenone is now being more widely used since the publication of the preliminary results of the CAST Study in the U.S.A.
Adult↗
T cell reactivity to the purified mycobacterial antigens p65 and p70 in leprosy patients and their household contacts.
T cell reactivity to the 70 and 65 kD (p70 and p65) protein antigens derived from Mycobacterium bovis BCG strain was studied by measuring the proliferative responses of peripheral blood mononuclear cells from members of an isolated Aboriginal community resident in the Torres Straits islands. In the nine index leprosy cases the pattern of responsiveness to the purified antigens paralleled that to whole sonicates from M. leprae and BCG. In the 40 contacts of the index cases, a high correlation was observed between the responses to p70 and p65 as well as to the crude sonicates. Significant T cell responses to the purified antigens, as well as the crude sonicates, were obtained with cells from the majority of contacts. Limiting dilution analysis of precursor frequencies in the contacts confirmed the immunogenicity of the purified antigens and excluded both a mitogenic component and the presence of suppressor cells in those moderate or low responders whose blood contained sufficient precursors to be tested. p70 appeared to be more potent in stimulating a proliferative response than p65 at equivalent protein concentrations. No correlation between responder status to either antigen and disease type was detected in families. These findings provide confirmation of the importance of p70 and p65 as major T cell immunogens in man and indicate that they are both potential candidates for inclusion in a bivalent vaccine for leprosy and tuberculosis.
Antigens, Bacterial↗
Inappropriate discharges by the implantable cardioverter defibrillator during postoperative testing: implications for intraoperative assessment.
Inappropriate shocks were delivered to a patient while in sinus rhythm by an implantable cardioverter defibrillator (ICD) during routine prehospital discharge testing. This was induced by the standard programmer when the "read" telemetry sequence was initiated. The ICD was removed and found to suffer from electrical artifact that was sensed as ventricular tachycardia during telemetry. To avoid inadvertent telemetry-induced shocks during routine testing, all ICDs should be interrogated, using a standard programmer, intraoperatively, with the unit in "defibrillation on" mode.
Aged↗
Evidence for a general neurotic syndrome.
Neurotic syndromes are defined by characteristic patterns of symptoms, but the validity of the distinction between one syndrome and another depends on associations between the syndromes and clinical history, or treatment response factors that are independent of the defining phenomena. In both a group of twin volunteers and a group of patients with panic disorder/agoraphobia, the lifetime experience of more than one diagnosis of a neurotic syndrome was common but there was no evidence of patterns of co-occurrence of diagnoses being associated with particular syndromes. Receiving a diagnosis was associated with abnormal scores on measures of neuroticism and locus of control, the extent of the abnormality increasing with the number of different diagnoses satisfied. It is argued that the concept of a general neurotic syndrome depends in part on the presence of such predisposing personality factors, and that reduction in this predisposition to neurosis should be the focus of treatment.
Adolescent↗
Prospective payment and the utilization of physical therapy service in the hospitalized elderly.
We studied the effect, in a university teaching hospital, of the prospective payment system (PPS) on utilization of physical therapy (PT), a non-reimbursable service; subjects were hospitalized patients aged 75 or older with non-PT-related diagnoses (myocardial infarction, pneumonia, congestive heart failure, and colectomy) and PT-related diagnoses (cerebrovascular accident and hip fracture). The proportion of patients referred for PT increased from 68 percent pre-PPS to 85 percent post-PPS for those with PT-related diagnoses and from 13 percent pre-PPS to 19 percent post-PPS for those with non-PT-related diagnoses. The mean number of sessions of PT decreased slightly for both groups: from 8.5 to 7.6 sessions for those with PT-related diagnoses and from 5.2 to 4.5 for those with non-PT-related diagnoses. In patients with PT-related diagnoses whose ambulatory status worsened during hospitalization, referrals for PT increased from 76 percent pre-PPS to 98 percent post-PPS. Referrals of comparable patients with non-PT-related diagnoses did not increase. Changes in provider education and efforts to reduce length of stay may account for these findings.
Aged↗
Epidemiological survey of coeliac disease and inflammatory bowel disease in first-degree relatives of coeliac patients.
One hundred and sixty-two of 182 patients with coeliac disease provided satisfactory details of family size and the prevalence of coeliac disease and inflammatory bowel disease among their first-degree relatives. Patients ranged in age from 11 months to 79 years with a mean age of 41 (+/- 23) years. Twenty patients had at least one first-degree relative with coeliac disease: a total of 25 of 861 relatives were affected (prevalence = 2904/100,000) compared with an expected 0.9 cases (prevalence = 100/100,000; p less than 0.001). Six relatives had inflammatory bowel disease (prevalence = 697/100,000) compared with an expected 1.3 cases (prevalence = 150/100,000; p less than 0.001). Five of these had ulcerative colitis, and one had Crohn's disease. The relative risk of ulcerative colitis is, therefore, five times greater for first-degree relatives of people with coeliac disease than for the general population (95 per cent confidence interval, 4.7-7.2). There is a clear association between coeliac disease and ulcerative colitis, which may point to factors involved in the aetiology of colitis.
Adolescent↗
Hand venous hypertension complicating arterio-venous fistula construction for haemodialysis.
Vascular complications of arterio-venous fistula construction for haemodialysis are rare. We report a patient who developed the hand venous hypertension syndrome with ulceration, 2 years after successful construction of a side-to-side radio-cephalic fistula at the wrist. The surgical treatment was ligation of the distended vein immediately distal to the fistula in the hand, and fistula function was preserved. The ulceration healed within 2 weeks of surgery. This complication had not been seen previously in the Dialysis Unit at Cardiff Royal Infirmary where, over the past 20 years, 800 fistulae have been constructed.
Adult↗
Fecal incontinence in an elderly man. Stanford University geriatrics case conference.
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Administration, Rectal↗
AIDS and the surgeon.
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Acquired Immunodeficiency Syndrome↗
Intraocular lens implantation: a model for the Third World.
Intracapsular cataract extraction has long been thought of as the appropriate technique to deal with the backlog of Third World cataract blindness. However, this operation may not be as sight effective as many believe. The authors offer their experience of intraocular lens implantation in the Torres Strait as a model for a more visually appropriate surgical cure for Third World cataract.
Cataract Extraction↗
Interstitial and free lung cells in acute inflammation in the guinea-pig.
Different cell types were studied in bronchoalveolar lavage fluid (BAL) and solid lung tissue of guinea-pigs. Whereas alveolar macrophages (AM) and eosinophils predominated in BAL, the proportion of AM and lymphocytes was highest in the lung tissue. After an inhalation exposure to LPS, the number of neutrophils increased rapidly in the lung tissue reaching a maximum after 4 hours, and more slowly in the airways reaching a maximum after 24 hours. This suggests that other mechanisms than secretion of chemotactic factors from AM, shown to be active up to 4 hours after exposure, are responsible for the later phase of the neutrophil invasion into the airways. Passive migration or other mediators may be involved.
Animals↗
Canine urinary incontinence study.
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Animals↗
Does non-clinical decompression stress lead to brain damage in abalone divers?
Abalone divers are subject to considerable decompression stresses and could be at risk of progressive cognitive impairment. A sample of abalone divers was compared with a sample of fishermen, by means of a battery of neuropsychological tests. No evidence of cognitive impairment was found in the divers, in spite of evidence of their exposure to decompression stress. The implications for other professional divers and for recreational underwater divers who follow standard decompression protocols are reassuring.
Adult↗