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Biomedical subjects

P Homolka

Publications and source records attributed to P Homolka.

14 recordsLinked to original sources

Optimization of the composition of phantom materials for computed tomography.

Using available data for photon attenuation and tissue composition, a computer code was developed for the optimization of the composition of phantom materials for diagnostic radiology. The code allows selection of attenuation data in a photon energy range from 1 to 150 keV and the choice of a suitable weight function in the energy interval chosen. For applications in CT imaging a weight function is available reflecting the contribution of the x-ray spectrum to the CT-signal. Several phantom materials for CT were optimized (body fat, trabecular bone, an average bone composition for C4 vertebrae and water) by varying the mineral components in a polymer base in order to adjust x-ray attenuation properties. Measurements with the water equivalent material (PSPP1) showed good agreement of calculated and measured HU values (AHU = 7.3 +/- 5.3 at 80 kVp and 4.0 +/- 2.7 at 140 kVp) and little variation of HU for tube voltages from 80 to 140 kVp. The method provides a fast and flexible means for obtaining optimized phantom materials for a large variety of tissue compositions and energy ranges.

Adipose Tissue↗

Temperature dependence of HU values for various water equivalent phantom materials.

The temperature dependence of water equivalent phantom materials used in radiotherapy and diagnostic imaging has been investigated. Samples of phantom materials based on epoxy resin, polyethylene, a polystyrene-polypropylene mixture and commercially available phantom materials (Solid Water, Gammex RMI and Plastic Water, Nuclear Associates) were scanned at temperatures from 15 to 40 degrees C and HU values determined. At a reference temperature of 20 degrees C materials optimized for CT applications give HU values close to zero while the commercial materials show an offset of 119.77 HU (Plastic Water) and 27.69 HU (Solid Water). Temperature dependence was lowest for epoxy-based materials (EPX-W: -0.23 HU degrees C(-1); Solid Water: -0.25 HU degrees C(-1)) and highest for a polyethylene-based material (X0: -0.72 HU degrees C(-1)). A material based on a mixture of polystyrene and polypropylene (PSPPI: -0.27 HU degrees C(-1)) is comparable to epoxy-based materials and water (-0.29 HU degrees C(-1)).

Biomimetic Materials↗

Production of phantom materials using polymer powder sintering under vacuum.

A technique is presented for the production of polymer-based phantom materials from solid polymer powders and various compounds added to adjust x-ray attenuation. After mixing of the finely grained components, the samples are solidified by a sintering process under vacuum. The method described allows a flexible and inexpensive production of phantom materials. Photon attenuation and density can be adjusted by suitable choice of base polymers and additives to mimic a large range of soft tissues and water.

Biophysics↗

Local calibrated bone mineral density in the mandible presented using a color coding scheme.

Calibrated information on bone mineral density (BMD) may be used in dental implantology to measure "bone quality". It can be used to estimate the expected primary implant stability preoperatively and to guide the surgeon in selecting optimum implant types and operation techniques. Using a preoperative dental computed tomography (Dental-CT) scan, all of this information can be obtained without additional examinations and thus without additional X-ray exposure of the patient. In contrast to bone mineral determination in other body regions, local BMD values are important in the jaw bone. Therefore, a regimen where color-coded information on local bone mineralization is superimposed on Dental-CT images is proposed using the original CT volumes as well as reformatted views.

Bone Density↗

In-vitro assessment of a registration protocol for image guided implant dentistry.

In this study a computer aided navigation technique for accurate positioning of oral implants was assessed. An optical tracking system with specially designed tools for monitoring the position of surgical instruments relative to the patient was used to register 5 partially or completely edentulous jaw models. Besides the accuracy of the tracking system, the precision of localizing a specific position on 3-dimensional preoperative imagery is governed by the registration algorithm which conveys the coordinate system of the preoperative computed tomography (CT) scan to the actual patient position. Two different point-to-point registration algorithms were compared for their suitability for this application. The accuracy was determined separately for the localization error of the position measurement hardware (fiducial localization error-FLE) and the error as reported by the registration algorithm (fiducial registration error-FRE). The overall error of the navigation procedure was determined as the localization error of additional landmarks (steel spheres, 0.5 mm diameter) after registration (target registration error-TRE). Images of the jaw models were obtained using a high resolution CT scan (1.5 mm slice thickness, 1 mm table feed, incremental scanning, 120 kV, 150 mAs, 512 x 512 matrix, FOV 120 mm). The accuracy of the position measurement probes was 0.69 +/- 0.15 mm (FLE). Using 3 implanted fiducial markers, FRE was 0.71 +/- 0.12 mm on average and 1.00 +/- 0.13 mm maximum. TRE was found to be 1.23 +/- 0.28 mm average and 1.87 +/- 0.47 mm maximum. Increasing the number of fiducial markers to a total of 5 did not significantly improve precision. Furthermore it was found that a registration algorithm based on solving an eigenvalue problem is the superior approach for point-to-point matching in terms of mathematical stability. The experimental results indicate that positioning accuracy of oral implants may benefit from computer aided intraoperative navigation. The accuracy achieved compares well to the resolution of the CT scan used. Further development of point-to-point/point-to-surface registration methods and tracking hardware has the potential to improve the precision of the method even further. Our system has potential to reduce the intraoperative risk of causing damage to critical anatomic structures, to minimize the efforts in prosthetic modelling, and to simplify the task of transferring preoperative planning data precisely to the operating room in general.

Algorithms↗

[A simple method for estimating effective dose in dental CT. Conversion factors and calculation examples for a clinical low dose protocol].

PURPOSE: An easily applicable method to estimate effective dose including in its definition the high radiosensitivity of the salivary glands from dental computed tomography is presented. Effective doses were calculated for a markedly dose reduced dental CT protocol as well as for standard settings. Data are compared with effective doses from the literature obtained with other modalities frequently used in dental care. METHODS: Conversion factors based on the weighted Computed Tomography Dose Index were derived from published data to calculate effective dose values for various CT exposure settings. RESULTS: Conversion factors determined can be used for clinically used kVp settings and prefiltrations. With reduced tube current an effective dose for a CT examination of the maxilla of 22 microSv can be achieved, which compares to values typically obtained with panoramic radiography (26 microSv). A CT scan of the mandible, respectively, gives 123 microSv comparable to a full mouth survey with intraoral films (150 microSv). CONCLUSION: For standard CT scan protocols of the mandible, effective doses exceed 600 microSv. Hence, low dose protocols for dental CT should be considered whenever feasable, especially for paediatric patients. If hard tissue diagnoses is performed, the potential of dose reduction is significant despite the higher image noise levels as readability is still adequate.

Calibration↗

A modular software system for computer-aided surgery and its first application in oral implantology.

Development of complex software applications in image guided therapy (IGT) is often complicated by the fact that providing basic functionality for image processing and user interaction from a graphical user interfaces (GUI) requires considerable manpower for software development. We present a programming environment that combines the high-level image processing library AVW, in-house developed patient-to-image registration procedures, and an interface to position measurement hardware. A specific application can be developed by using Tcl/Tk, a simple platform-independent scripting language, for GUI development. This environment was applied to developing VISIT, a navigation system for computer-aided implant dentistry. VISIT is presented as a result of this paper. Parts of the development environment were made accessible to the public. Future work includes the implementation of video input for connecting ultrasound or fluoroscopy units. We conclude that our approach is well suited to accelerate the development of exploratory new applications of IGT.

Dental Implantation↗

[Magnetic resonance tomography in dental radiology (dental MRI)].

PURPOSE: To demonstrate the usefulness of Dental-MRT for imaging of anatomic and pathologic conditions of the mandible and maxilla. METHODS: Seven healthy volunteers, 5 patients with pulpitis, 9 patients with dentigerous cysts, 5 patients after tooth transplantation and 12 patients with atrophic mandibles were evaluated. Studies of the jaws using axial T1- and T2-weighted gradient echo and spin echo sequences in 2D and 3D technique have been to performed. The acquired images were reconstructed with a standard dental software package on a workstation as panoramic and cross sectional views of the mandible or maxilla. RESULTS: The entire maxilla and mandibula, teeth, dental pulp and the content of the mandibular canal were well depicted. Patients with inflammatory disease of the pulp chamber demonstrate bone marrow edema in the periapical region. Dentigerous cysts and their relation to the surrounding structures are clearly shown. After contrast media application marked enhancement of the dental pulp can be found. CONCLUSION: Dental-MRT provides a valuable tool for visualization and detection of dental diseases.

Diagnostic Imaging↗

Laser shaping of corneal transplants in vitro: area ablation with small overlapping laser spots produced by a pulsed scanning laser beam using an optimizing ablation algorithm.

Area laser lathing and trephination of donor corneas is used to produce different types of grafts for human transplantation. 193 nm (ArF excimer) laser radiation is used, since this is known to give a non-thermal laser-tissue interaction with a minimal zone of tissue damage. To guarantee the highest degree of flexibility concerning the overall shape of the grafts as well as their thickness profiles, we use a small (compared with the area to be ablated) scanning laser spot. For area lathing of the tissue we have developed a new ablation algorithm (optimized scanning laser ablation, OSLA) that can be applied to lathe and perforate any tissue--with concave (as in this application), convex or plane surface geometry--where surface precision and smoothness are key issues. Using OSLA with the Excimer Laser Corneal Shaping System (a tool for in vitro fabrication of all kinds of corneal transplants like donor buttons for keratoplasty, lamellar grafts for epikeratoplasty and refractive lenticules) enabled us to produce all types of corneal grafts with very high precision. This is considered to be a major improvement towards the production of refractive lenticules.

Algorithms↗

Physical fitness in lignite miners.

The purpose of this study was to determine physical fitness level of lignite miners in the Czech Republic. The authors have examined a representative group of 152 active lignite miners by bicycle spiroergometry. The duration of employment in coal mines ranged between 5 and 32 years. The average age was 43.1 +/- 4.7 years. The miners had an average peak oxygen consumption 2.9 +/- 0.5 l.min-1, corresponding to 99.7 +/- 20.4% of the predicted maximal oxygen consumption. Physical fitness of lignite miners was comparable with reference values for healthy men in Czech population. The level of physical fitness did not correlate with the length of exposure to underground work.

Adult↗

Comparison of two protocols used in exercise testing in chronic heart failure patients.

UNLABELLED: Spiroergometrical testing with the load graded upto symptom-limited maximum with the determination of anaerobic threshold begins to be a routine method in exercise testing of cardiac patients. Functional parameters according to available data depend on the source of load and may be influenced by the protocol of testing, too. That is why we decided to compare two protocols used in chronic heart failure patients exercise testing. 11 male and 3 female patients (NYHA II, III) suffering from chronic heart failure were subjected to the symptom-limited tests (protocol A-0.25 W.kg (-1/3 minutes with one minute breaks; protocol B-25 W + 10 W/2 minutes). There was no statistically significant differences in the symptom-limited values of main functional parameters. The AT level parameters did not differ significantly, as well. Anaerobic threshold could be determined in all patients using the protocol A and in 11 cases using the protocol B. The difference in rates was not statistically significant. The workload duration using the protocol B was significantly shorter (9.7 +/- 3.8 minutes vs. 16.4 +/- 3.6 minutes). CONCLUSIONS: Protocol B is less time demanding and therefore it is more suitable for determination of the symptom-limited parameters in the clinical routine. Anaerobic threshold can be determined by protocol A more often than by protocol B. Therefore, protocol A appears to be more suitable for the individual prescription of the appropriate physical activity and for scientific purposes, too.

Anaerobic Threshold↗

Corneal lathing using the excimer laser and a computer-controlled positioning system.

PURPOSE: To present the excimer laser corneal shaping system (ELCS-S), an add-on device to the Keratom, a commercially available 193-nm excimer laser built by Schwind. METHODS: The system is designed for the preparation of donor corneas under sterile conditions using the ultraviolet laser to offer greatest possible flexibility. Lenticules for planolamellar grafting and refractive epikeratoplasty, as well as donor buttons for penetrating keratoplasty can be computer-designed by the surgeon or technician and lathed with the system. RESULTS: Using the excimer laser corneal shaping system (ELCS-S) on human donor corneas, the central surface of the epikeratoplasty lenticule exhibited only narrow, flat concentric notches corresponding to the single lathing steps. Transmission electron microscopy revealed a damage zone of less than 0.3 microm in close approximation to the treated surface. The final thickness revealed a difference of less than +/-53 microm from the intended, initially programmed value. Ultrastructural studies showed the perpendicular stromal surface of the penetrating keratoplasty buttons to be smooth with minimal protrusion of Descemet's membrane. Endothelial injury was observed in a zone averaging between 40 and 100 microm adjacent to the cutting edge only. CONCLUSION: The excimer laser corneal shaping system (ELCS-S) allows a computer-controlled, surgeon-designed, sterile preparation of lamellar and penetrating corneal grafts with the use of the excimer laser. This could offer significant advantages in comparison to presently available systems for lamellar dissection and trephination.

Computers↗

Spin-offs from blood pressure and heart rate studies for health care and space research.

Evidence here cited underlies resolutions at international meetings to initiate a chronobiology project for health improvement. This project demonstrates expeditiously the feasibility and the health benefits of incorporating chronomedical considerations in the diagnosis, treatment, and prevention of one (or a few closely related) vascular (and oncological) diseases, that have high awareness and importance in the public perspective. Thereby, chronomedicine should become a mainstream basic and applied speciality leading to continual improvement in national/international health status. Reference data obtained for health care can also serve to give a better understanding of the relationship between the terrestrial biosphere and cosmoi near and far.

Blood Pressure↗