Biomedical subjects
P Horstmann
Publications and source records attributed to P Horstmann.
[Pneumococcal meningitis. A 40-year case load].
Eighty-four cases of pneumococcal meningitis were admitted to the medical-epidemic department C, Odense Hospital, during the period from 1940 to 1980. 39% of the patients were under 10 years, 17% under one year, whereas 23% were over 50 years. The proportion males to females in all groups was approximately 3:2. Pneumococcal meningitis, like other types of meningitis, responds dramatically to antibiotic treatment, but must still be considered a serious disease. Following treatment with a combination of penicillin, streptomycin, sulphonamides and chloramphenicol the mortality during the period 1952 to 1980 decreased to 12.7%. The fatal cases after 1952 all occurred during the years 1975-77. Patients with meningitis are very sensitive to overhydration. It was therefore decided to restrict intravenous administration in these patients. Following the introduction of this regimen the mortality decreased again. The prevailing cause of death from meningitis during the antibiotic era was brain edema, which may occur even if the inflammation of the meninges has vanished. Therefore it is considered important to avoid overhydration in these patients.
[The analysis of polycyclics in vegetable samples].
PAH analyses in vegetables are often difficult to carry out; therefore two different clean-up methods, which allow elimination of interfering matrix components such as essential oils, waxes, carotinoids and chlorophylls were developed. Clean-up of 32 different vegetables samples consisted of either Bio-Beads S-X3 chromatography or semi-preparative HPLC on silica gel Si-60. PAH were determined by capillary GC-MS, which allowed the application of deuterium-labeled internal standards. The results are presented; higher PAH contamination was detected in kale and parsley.
[Diagnosis of epileptic changes in personality].
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[Imported malaria. Analysis of 27 cases].
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[Determination of serum creatine phosphokinase activity as an aid in the clarification of attacks].
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Delayed attacks of malaria in visitors to the tropics.
Out of 80 Danish college students and their teachers visiting the Middle East, West Pakistan, and India by bus in two four-month journeys during the summer and autumn of 1971, six individuals developed an apparently first attack of vivax malaria within seven to nine months after their return to Denmark. No cases of malaria were seen in the group during the journeys. Prophylaxis with chloroquine (Resochin) was strictly observed when visiting the areas in which malaria is endemic.All cases responded rapidly and completely to a full course of treatment with chloroquine. The most probable cause of the delay of the clinical manifestations is drug prophylaxis, which can prevent a clinical attack but not always eradicate the parasite.
[Depression and occupation. Social aspects of endogenous depression].
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[The significance of imported disease in daily medical practice].
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[Metabolism of ethyl alcohol in the organism].
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[Tropical medicine problems in the light of a study tour to France].
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Ischaemic heart disease in middle-aged men. Prevalence comparisons in Europe.
The authors report the results of a collaborative study of the prevalence of ischaemic heart disease in 6 samples of middle-aged male clerical workers, drawn from 5 European countries and covering in all 4522 subjects. Detailed standardization of data-collection methods and of coding, analysis and tabulation was undertaken.Estimated prevalence rates for angina and history of possible infarction, based on the use of a standard questionnaire, showed significant variation between samples, but the validity of international comparisons of symptoms remains unproven. Prevalence rates for ischaemic-type ECG findings were high everywhere, and mostly showed no significant variation between the groups studied. Central coding of ECG findings proved essential to the making of unbiased comparisons. Neither the prevalence rates for symptoms nor those for ECG findings in these samples were recognizably correlated with the corresponding national mortality rates for ischaemic heart disease.Several possible risk factors were studied, but the only one found to be consistently associated with ischaemic heart disease was a raised blood pressure. Cigarette smoking was strongly associated with bronchitic symptoms and dyspnoea, but an association with heart disease was not demonstrated.
[Observations of the committee on rehabilitation concerning the establishment of rehabilitation clinics].
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