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Biomedical subjects

P Hourdebaigt-Larrusse

Publications and source records attributed to P Hourdebaigt-Larrusse.

13 recordsLinked to original sources
PubMed1985

[A new case of lupus induced by acebutolol].

Few such observations of beta-blocker-induced lupus have been published in the medical literature. In the index case, the usual criteria were present. Acebutolol withdrawal resulted in rapid clinical improvement. Antinuclear antibodies are still present after nine months follow up. Pathogenic hypotheses are discussed.

Acebutolol↗
PubMed1985

[Mianserin in acute cardiopathies. 27 cases recorded in a medical intensive care unit].

The cardiovascular tolerance of mianserin, a tetracyclic antidepressant with anxiolytic properties, at a dose of 30 to 90 mg/day, is studied in 27 patients affected by acute cardiopathies and attended for two months by a cardiologist and a psychiatrist. From the cardiovascular point of view progression is as usual, with two deaths from recurrence of a massive infarct, prognosis in agreement with the literature. A clinical examination, the electrocardiogram and Holter monitoring did not reveal any side effects. Psychiatric progression is favourable, in conformity with studies of the antidepressive and anxiolytic properties of mianserin. These results are compared with those of tricyclic antidepressants usually employed up to now in similar cases, with their well-known cardiovascular risks, particularly in the case of an overdose. The authors thus suggest the use of mianserin in the acute phase of all cardiopathies, in cases of depression and/or anxiety, because it is efficacious and well-tolerated, whereas a tricyclic antidepressant would not be easy to handle, dangerous, indeed formally contra-indicated. By extension, they suggest its use in chronic cardiopathies.

Acute Disease↗
PubMed1983

[Cardiac hydatidosis].

Cardiac localizations in hydatid disease are uncommon and often latent. A mass at the apex of the heart was discovered in a 42-year-old patient who presented with abnormal EKG repolarization. This mass was anechoic. Coronography demonstrated an avascular lesion with displaced coronary arteries. A hydatid cyst was suspected. No other visceral localizations of hydatid disease were detected. The patient refused surgery and was seen two years later with acute pericarditis and rapidly developing cardiac tamponade. A very large amount of pericardial fluid and a single hydatid cyst were discovered upon surgery. The cyst was aspirated and sterilized and the protruding cyst wall was resected. A severe postpericardotomy syndrome and positivation of hydatid disease serological tests occurred during the postoperative course. The patient was then given flubendazole. Prompt recovery occurred and the patient is still doing well under therapy two years later. In hydatid disease, an isolated cardiac localization is uncommon and often latent and may be revealed by complications. Prompt diagnosis should be made by echocardiography.

Adult↗
PubMed1983

[Neurologic complication of lymphography. Apropos of a case].

A lymphography was performed as a diagnostic procedure in a 69-year-old female patient hospitalized for protracted fever. Akinetic mutism with left hemiparesis occurred 10 minutes after the injection of ultrafluid lipiodol. The patient died 13 days later. Neurologic complications of lymphography are extremely rare but may be life-threatening. Speculations as to the mechanisms which may be responsible for these complications, through a modification of the usual distribution of the contrast media, include lymphovenous shunts, lymphatic vessel compression or obstruction, pulmonary arteriovenous shunts and right-to-left intracardiac shunts. These mechanisms may facilitate cerebral embolization of the contrast media. Indications of lymphography must be restricted in patients with patent lymphatic obstruction.

Aged↗
PubMedDate not supplied

[Chronic constrictive pericarditis complicating an apparently stable rheumatoid arthritis. Report of a new case (author's transl)].

The authors report a case of constrictive pericarditis complicating an apparently stable sero-negative rhumatoïd arthritis, a rarely described pathological association. The patient had a serious polyserositis due to an extremely marked and inflammatory pericardial constriction. The rhumatoïd origin was confirmed by pericardial effusion, histological and immunofluorescent studies. The inflammatory pericardial process rendered pericardiectomy virtually impossible and resulted in a fatal outcome.

Adult↗
PubMedDate not supplied

[Lactic acidosis and intensive care. 16 cases (author's transl)].

Sixteen cases of lactic acidosis are reported: 7 phenformin treated diabetes, 5 cardiovascular diseases (2 myocardial infractions, 2 pulmonary embolisms, 1 heart failure). In 2 patients no etiology was found. Concomittant renal failure or liver diseases were found in respectively 9 and 4 cases. Patients presented the usual criteria of lactic acidosis: clinical, polypnea, severe hypotension (9/16), peripheral symptoms of shock (12/16), hypothermia (9/16), abdominal pain (9/16): biologically, acidosis (pH = 6,99 +/- 0,01, HCO3- = 5,9 +/- 1,5 mmol), hyperlactatemia (14,1 +/- 3,6 mmol/l) with hig lactate/pyruvate ratio (105 +/- 73), and anion gap (24,3 +/- 4,2 mmol/l). Sodium bicarbonate infusion was performed in all cases (2,5 to 42 mmol/kg). Few cases required volhemic expansion or furosemid induced diuresis. One patient was treated with extrarenal dialysis. 13 patients were alkalinised with less than 185% of estimated deficit measured from alkalin reserve: 12 died. 3 patients received 185% more than this deficit, associated with furosemid (1,8 to 12,5 mg/kg): only one patient died ten days after by casual disease, with lactatemia of 3,2 mmol/l. In spite of the small number of patients, these findings suggest that an early and massive alkalinisation, with large doses of furosemid, can improve the severe lactic acidosis prognosis.

Acidosis↗