PubMed Health⌕ Search

Biomedical subjects

P Hussain

Publications and source records attributed to P Hussain.

11 recordsLinked to original sources
PubMed2004

The feasibility of telemedicine for the training and supervision of general practitioners performing ultrasound examinations of patients with urinary tract symptoms.

Ultrasound examinations were carried out by a general practitioner on patients who presented with lower urinary tract symptoms. To assist in the interpretation of ultrasound anatomy, still images were captured during the ultrasound examination and transmitted to a university expert. In total 15 telemedicine sessions were conducted, using PC-based videoconferencing equipment connected by ISDN at 128 kbit/s. Fifteen patients were randomly selected and both the transmitted and hard-copy images (printed on thermal paper) were graded for technical quality. Data were missing for 13 of the possible 105 paired comparisons, as some images could not be evaluated. Overall agreement between the technical quality scores for the transmitted and hard-copy images was poor (weighted kappa=0.04). The 105 transmitted images were also rated for their diagnostic quality: 90% were classified as diagnostic and 10% were judged to be non-diagnostic. The results show the feasibility of tele-ultrasound in primary care. The general practitioner concerned benefited from regular ultrasound training and supervision, and achieved a satisfactory level of clinical competency in scanning the prostate, bladder and kidneys.

Clinical Competence↗
PubMed1999

Evaluation of a training and diagnostic ultrasound service for general practitioners using narrowband ISDN.

We carried out a four-month pilot study of telemedicine for the delivery of training and diagnostic ultrasound services for general practitioners (GPs). Two health centres and a district general hospital were linked using ISDN (128 kbit/s) and PC-based videoconferencing units. Sixteen videoconferencing sessions were conducted, with 64 patients scanned over the ISDN link for a range of clinical conditions. Nine cases of pathology were demonstrated and confirmed by a consultant radiologist. A total of 229 images were transmitted using the store-and-forward facility, of which 194 (85%) images were of diagnostic quality and 35 (15%) were regarded as non-diagnostic. Allowing for sampling error, we would expect 79-89% of stored images to provide diagnostic information at a 95% confidence level. A total of 115 store-and-forward images (SAFI) were randomly selected and compared with hard-copy images (HCI) for technical quality. There was a significant difference in the quality of images. The results show that SAFI are far superior to HCI, traditionally used by clinicians for making primary diagnosis and that the superior quality of the SAFI improved diagnostic accuracy. This pilot study showed a high degree of confidence in videoconferencing for training GPs to carry out ultrasound clinics, enhancing their ability to make accurate diagnoses, and providing them with immediate access the second and higher opinion.

Education, Medical, Continuing↗
PubMed1994

Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene.

Point mutations in ras protooncogenes and in the p53 tumor suppressor gene are common in many forms of human cancer. The identification of carcinogens which are responsible for their induction in humans is of great interest because it may suggest measures for disease prevention. Furthermore, the load of somatic mutations in cancer-related genes in premalignant tissues may become a useful parameter for risk assessment. For the measurement of such mutations, highly sensitive genotypic mutation systems are required which avoid the selection and clonal expansion of cells on the basis of a mutated phenotype. We have developed the restriction fragment length polymorphism/polymerase chain reaction method for genotypic mutation analysis and applied it to the study of the mutability of hot-spot codons in c-H-ras1 and p53 genes with human carcinogens. In particular, we studied the mutability of codons 247-250 of p53 with the mycotoxin aflatoxin B1 (AFB1) in human hepatocytes. AFB1 preferentially induced the transversion of guanosine to thymidine in the third position of codon 249, generating the same mutation which is found in a large fraction of hepatocellular carcinomas from regions of the world with AFB1-contaminated food. Our results are in support of AFB1 as an etiological factor for hepatocellular carcinoma in AFB1-contaminated areas. In an ongoing study we are comparing the load of mutations in hot-spot codon 12 of c-H-ras1 in urinary bladder carcinoma and in normal tissue, by restriction fragment length polymorphism/polymerase chain reaction. We observed moderately elevated abundances of guanosine to thymidine transversions in the middle position of codon 12 in tumor DNA. These results may reflect a mutator phenotype of the tumor tissue or they could be the consequence of the heterogeneity of the biopsies which were analyzed.

Aflatoxin B1↗
PubMed1991

Ethnicity, health and dental care--perspectives among British Asians: 1.

In some areas, Asian communities constitute a sizeable proportion of the population around a general dental practice, yet some have never been to a dentist in the whole of their lives. A significant number of others fail to visit a dentist regularly. This two-part article aims to clarify some of the issues relating to dental care of minority groups, with particular reference to Asian communities. An outline is given of some general and dental health issues which are of particular significance to dental practitioners, as they strive to provide continuous care to the whole population. Part 1 identifies dental health problems characteristic of British Asians, Part 2 will examine some of the barriers to care.

Adolescent↗
PubMed1991

Ethnicity, health and dental care--perspectives among British Asians: 2.

In some areas, Asian communities constitute a sizeable proportion of the population around a general dental practice, yet some have never been to a dentist in the whole of their lives. A significant number of others fail to visit a dentist regularly. This two-part article aims to clarify some of the issues relating to dental care of minority groups, with particular reference to Asian communities. part 1 identified dental health problems characteristic of British Asians, Part 2 now examines some of the barriers to care.

Adult↗
PubMed1990

Ankyrin of the ocular lens.

Ankyrin was identified in the human, bovine and chicken lens as a protein of molecular weight 216 kilodaltons. It is specifically extracted from association with the fiber cell plasma membranes by high-ionic-strength salt solution and is predominantly found in young fiber cells. A protein which is unrelated to plakoglobin, protein 4.1 or ankyrin is also specifically extracted by high-salt solution.

Animals↗
PubMed1990

Use of ultrasound in Nepal.

Although for a Third World country like Nepal the provision of an ultrasound machine may represent a considerable capital outlay, once installed it is a versatile diagnostic tool, non-invasive, relatively inexpensive to run and requiring very little patient preparation and no in-patient beds. Ultrasound, in the hands of a skilled ultrasonographer, can provide immediate, accurate and invaluable diagnostic information to the clinicians in a range of bizarre and advanced clinical conditions.

Adolescent↗
PubMed1990

The use of ultrasound in the management of primary psoas abscess.

Whereas psoas abscess secondary to many local intra- and extra-peritoneal septic processes is well recognised, primary psoas abscess is much less common and the diagnosis is often delayed, leading to significant morbidity and mortality. A case of primary psoas abscess is described and the role of ultrasound in the investigation and management is discussed.

Abscess↗
PubMed1985

Study of awareness during noninhalational anaesthesia.

Forty-five adult patients underwent a noninhalational anaesthetic method for investigation of awareness during surgery and recall of events associated with surgery in postoperative period. All the patients were divided into two groups. The first group of patients were male and had upper abdominal operations. The second group were female and had lower abdominal operations. No significant difference was found between these two groups either in requirements of depth of anaesthesia or in the evidence of per-operative awakefulness. Eighty percent patients of both the groups showed various signs of peroperative awakefulness but did not recall any events associated with surgery in the postoperative period. There was no report of dream either.

Adult↗