Current issues in occupational lung disease.
Explore the source record for details and available documents.
Environmental Exposure↗
Biomedical subjects
P I Harber
Publications and source records attributed to P I Harber.
Initial clinical evaluation of a new Rocky Mountain spotted fever vaccine of tissue culture origin.
Currently available Rocky Mountain spotted fever (RMSF) vaccines are relatively ineffective in preventing infections in humans and contain considerable amounts of contaminating egg protein. A new formalin-inactivated vaccine was prepared by sucrose density gradient centrifugation of the Sheila Smith strain of Rickettsia rickettsii grown in chick embryo cell tissue culture. The new product has greater protective immunogenicity in rheusus monkeys and guinea pigs than commercial vaccines. Six volunteers without immunologic evidence of prior exposure to RMSF received from one to three inoculations of the vaccine diluted 1:10, and there were two benign local reactions. Titers of antibody (determined by microagglutination and indirect fluorescence techniques) increased in all recipients as did lymphocyte tranformation responses to specific rickettsial antigen. Ten volunteers were immunized twice with vaccine diluted 1:3; there were no local reactions, and immunologic responses were similar to those in the six volunteers in the first group. The proper dosage and immunization schedule for the vaccine must be determined in further studies.
Agglutinins↗
Respiratory depression from alkalosis and opioid interaction in man.
Explore the source record for details and available documents.
Adult↗
Worksite and personal factors associated with carpal tunnel syndrome in an Egyptian electronics assembly factory.
The study objective was to identify personal and work-related risk factors associated with carpal tunnel syndrome (CTS) in electronics assembly, operators relative to clerical workers in the same factory. Of 422 workers in a television assembly factory located in Ismailia, Suez Canal Area, Egypt, 198 (46.9%) participated. The electronics assembly workers were more likely to report CTS (odds ratio = 11.41, 95% CI = 3.6 -40.26) than were the clerical workers. The significant risk factors were longer work years (odds ratio = 1.11, 95% CI = 1.03-1.20) and precision-type hand grip (odds ratio = 6.5, 95% CI = 1.08-39.23). The results suggest an association between electronics assembly and CTS. Work years and precision grip are possible risk factors for CTS and should be studied more thoroughly. Tools to reduce the need for precision grip may help reduce CTS.
Adult↗