Biomedical subjects
Publications and source records attributed to P Ianev.
The clinical picture and pathologoanatomical changes of one case with Hamman--Rich syndrome are described, with the diagnosis made while still living of a middle aged woman, textile worker with a subchronic course of the disease. The role of the organic textile dust is admitted to be the triggering factor for the development of the disease according to the mechanism of autoallergization.
The most frequent abdominal complaints in chronic pyelonephritis are analyzed and one patient is described, who with the exacerbation of the disease manifested the clinical picture of acute abdomen. The involvement of visceral-dermal reflexes with hyperalgesia, muscular defense, vomiting, meteroism and disturbances in intestinal motility imitated the picture of acute abdominal drama, forcing the surgical intervention. The varied abdominal symptomatics in about 20 per cent of the cases with chronic exacerbated pyelonephritis, should be critically assessed by the therapeutists.
The authors have treated 23 patients with duodenal ulcer under clinical and partially under out-patient department conditions with cimetidin 0.8 g daily in the course of 25 days. The results obtained are as follows: in 100 per cent -- abating of all clinical symptoms, in 56.25 per cent -- elimination of niche at X-ray examination and in 18.75 per cent -- diminution of ulcer size. The authors lay stress upon the good tolerance of the drug and absence of side effects.
The authors present the results from the study of the cellular immunoreactivity of immunocompetent lymphoid cells in 23 patients with gastric carcinoma and 30 patients with ulcer disease of the stomach, by applying the test for the confirmation of rosette-forming T-lymphocytes, according to the method of Bach and Lay. A significantly decreased number of T-lymphocytes was found both in case of ulcer disease of the stomach and gastric carcinoma. Best manifested is the depression of the cellular immunoreactivity in gastric carcinoma and it corresponds to the degree of the generalization of the process.
The studies of the ultrastructure of parietal cells in chronic gastritis revealed changes in mitochondria manifested by clearing of the matrix, reduction in the number and length of christae and partial or complite vacuolation of the cytoplasm. Changes of intracellular microtubules and endoplasmic reticulum were also found. The described disorders in the ultrastructure of parietal cells in chronic gastritis are the morphological substrate of disoredrs in hydrochloric acid secretion in this disease.
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