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P Iriarte

Publications and source records attributed to P Iriarte.

6 recordsLinked to original sources
PubMed1996

PCR-RFLP analysis of the large subunit (23S) ribosomal RNA genes of Campylobacter jejuni.

Forty-seven strains of Campylobacter jejuni were examined by PCR-RFLP analysis of 23S rRNA genes. Seven different molecular profiles were detected by a combination of HpaII AluI and DdeI digest analysis. Most (83%) strains, including those with different Penner serotypes and from different hosts, had the same molecular profiles. The high level of conservation apparent within the 23S rDNA sequences confirmed their value as targets in species-specific PCR identification assays but not for subtypic discrimination within Camp. jejuni.

Campylobacter jejuni↗
PubMedDate not supplied

A prospective and multicenter safety-monitoring study of a short up-dosing schedule of immunotherapy with a mass-units-standardized extract of mites.

A prospective, multicenter pharmacovigilance study was carried out to evaluate the safety of a new 7-dose treatment schedule of subcutaneous immunotherapy as opposed to the conventional 13 doses normally recommended. The study was carried out in 14 centers and included 261 patients (children and adults) with respiratory allergic disease due to sensitization to mites (Dermatophagoides pteronyssinus and/or farinae). A total of 2290 doses were administered under the direct supervision of the participating specialists. One hundred and ten reactions in 63 patients (24.1%) were recorded, representing 4.8% of the total doses administered. Most of the reactions (98) were local. Only 12 were systemic (0.5% of the administered doses) and occurred in 10 patients (3.8% of the sample). Ten reactions reverted quickly with rescue medication. The maintenance dose had to be lowered in one patient and another patient was withdrawn from the study after suffering two asthmatic crises after two consecutive doses. In view of the results obtained, we can conclude that the new schedule shows an acceptable tolerance profile and does not present a greater risk of reactions than the conventional scheme of 13 doses using an identical extract. Moreover, the new schedule represents substantial savings in the number of doses and visits required to reach the maintenance dose.

Adult↗