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Biomedical subjects

P J Berkowitz

Publications and source records attributed to P J Berkowitz.

3 recordsLinked to original sources

Presence of circulating immune complexes in patients with peripheral corneal disease.

Seventeen patients with peripheral corneal thinning and ulcers (four with Mooren's corneal ulcer, five with Terrien's marginal degeneration, and eight with collagen vascular disease) were tested for immune complexes in their serum. Circulating immune complexes, measured by Raji cell and C1q binding assays, were compared with levels in serum samples from normal controls and seven patients with staphylococcal marginal corneal ulcers. Comparison with normal controls showed significantly higher levels of circulating immune complexes in patients with collagen disease by the C1q binding assay and in patients with Mooren's ulcer by the Raji cell assay. Circulating immune complexes may play a role in the pathogenesis of Mooren's ulcer and marginal ulceration in the presence of collagen vascular disease. Their presence, however, may represent an epiphenomenon nonspecifically associated with corneal ulceration.

Adolescent↗

Surgical wound leaks associated with sodium hyaluronate (Healon).

Sodium hyaluronate (Healon) is an ideal material for protecting the cornea during intraocular lens implantation and protecting donor corneal material during corneal transplantation. Although it has been advocated for maintaining filtering blebs during trabeculectomy and as a vitreous replacement, its main benefit to ophthalmic surgeons is its protection of the cornea during anterior segment surgery.

Adult↗