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Biomedical subjects

P J Carek

Publications and source records attributed to P J Carek.

At least 19 recordsLinked to original sources
PubMed2001

Exercise-induced anaphylaxis and urticaria.

In a select group of persons, exercise can produce a spectrum of allergic symptoms ranging from an erythematous, irritating skin eruption to a life-threatening anaphylactic reaction. The differential diagnosis in persons with exercise-induced dermatologic and systemic symptoms should include exercise-induced anaphylaxis and cholinergic urticaria. Both are classified as physical allergies. Mast cell degranulation with the release of vasoactive substances appears to be an inciting factor for the production of symptoms in both cases. Exercise-induced anaphylaxis and cholinergic urticaria can be differentiated on the basis of urticarial morphology, reproducibility, progression to anaphylaxis and response to passive warming. Diagnosis is usually based on a thorough history and examination of the morphology of the lesions. Management of acute episodes of exercise-induced anaphylaxis includes cessation of exercise, administration of epinephrine and antihistamines, vascular support and airway maintenance. Long-term care may require modification of or abstinence from exercise, avoidance of co-precipitating factors and the prophylactic use of medications such as antihistamines and mast cell stabilizers.

Anaphylaxis↗
PubMed2001

Diagnosis and management of osteomyelitis.

Acute osteomyelitis is the clinical term for a new infection in bone. This infection occurs predominantly in children and is often seeded hematogenously. In adults, osteomyelitis is usually a subacute or chronic infection that develops secondary to an open injury to bone and surrounding soft tissue. The specific organism isolated in bacterial osteomyelitis is often associated with the age of the patient or a common clinical scenario (i.e., trauma or recent surgery). Staphylococcus aureus is implicated in most patients with acute hematogenous osteomyelitis. Staphylococcus epidermidis, S. aureus, Pseudomonas aeruginosa, Serratia marcescens and Escherichia coli are commonly isolated in patients with chronic osteomyelitis. For optimal results, antibiotic therapy must be started early, with antimicrobial agents administered parenterally for at least four to six weeks. Treatment generally involves evaluation, staging, determination of microbial etiology and susceptibilities, antimicrobial therapy and, if necessary, debridement, dead-space management and stabilization of bone.

Acute Disease↗
PubMed2001

Graduate survey of the South Carolina Area Health Education Consortium family practice residency programs.

The results of this study demonstrate several interesting characteristics of the graduates of the SC AHEC associated family medicine residency programs: 45 percent practice in South Carolina, 63 percent live further than 120 miles from their residency program, 96 percent are satisfied with their specialty choice, and 56 percent are involved in teaching medical students and residents. Furthermore, these graduates have the following tendencies: to practice in the traditional solo or group practice; to practice in a suburban community, town or rural community and a setting size less than a population of 100,000 persons; to care for the aging adult and geriatric population; to provide nursing home care; and to utilize house calls to provide patient care). As the current health care system continues to be redesigned, this information will be essential for assessment and planning purposes.

Adult↗
PubMed2000

Drug therapy for obesity.

Obesity is a common health problem in the United States, and effective treatment is challenging. Obesity is associated with an increased mortality rate and risk factors such as hypertension, hyperlipidemia and diabetes mellitus. Numerous treatments are available for obesity. Behavioral therapy, surgery and pharmacologic treatment have been used with varying degrees of success. Older anorectic agents have significant side effects and limited benefit, and some have even been withdrawn from the U.S. market because of a possible association with cardiovascular complications. The safety of newer agents must be extensively evaluated before widespread use is recommended. Therefore, behavioral therapy, including regular exercise and the development of healthy eating habits, continues to be the best treatment for long-term weight loss.

Anti-Obesity Agents↗
PubMed2000

The pharmacist's role in promoting optimal antimicrobial use.

Optimal use of antimicrobials is essential in the face of escalating antibiotic resistance, and requires cooperation from all sectors of the health care system. Although antibiotic-restriction policies in the hospital setting are important in altering microbial susceptibility patterns, an overall reduction in antibiotic prescriptions in the outpatient setting is more likely to significantly impact antibiotic resistance. Education of providers, application of clinical practice guidelines, audit and feedback activities, and multifaceted interventions all have had an effect in altering antibiotic prescribing in a research setting. Clinicians must alter antibiotic prescribing for the treatment of infectious diseases, and patients must change their perception of the need for these drugs. Pharmacists can play a major role through clinician education and focused clinical services. With cooperation of health care teams, the effectiveness of available antibiotics may be sustained and the threat of resistance minimized.

Anti-Bacterial Agents↗
PubMed2000

Recruitment behavior and program directors: how ethical are their perspectives about the match process?

OBJECTIVE: This study examined family practice residency directors' perspectives on the 1999 National Resident Matching Program (NRMP) process and identified directors' expectations for students' recruitment behavior. METHODS: Subjects were the family practice residency program directors. A 22-item written questionnaire was mailed to each director. The questions related to the directors' perceptions of the following issues: applicants interviewing in more than one specialty, communication initiated by programs or applicants, commitments made to applicants and by applicants, ethical dilemmas faced by the program director, and the NRMP process itself. Descriptive statistics were reported. RESULTS: Only a few of the residency program directors (9.1%) felt that it was ethically wrong for an applicant to interview in more than one specialty. However, most program directors (83%) indicated that the knowledge of an applicant interviewing in more than one specialty had a "significant" negative or "some" negative effect on the applicant's rank order. Ninety-five percent of program directors indicated that they engage in follow-up communication with applicants following the formal interview. Almost all program directors (98%) reported that at least some applicants contact them following the formal interview to inform them that the program was a "high" or No. 1 rank-order choice. The majority of program directors (94%) felt that the NRMP process placed their program in the position of having to be dishonest with applicants to match their top choices. CONCLUSIONS: The results of the study indicate that the actions of many program directors and applicants may not be consistent with the written policies of the NRMP.

Administrative Personnel↗
PubMed1999

The preparticipation physical examination history: who has the correct answers?

OBJECTIVE: To examine whether discrepancies exist between information given by parents and student athletes during the annual preparticipation physical examination (PPE) for athletics, and if present, whether the discrepancies occurred in areas of clinical significance to sports medicine and clearance for participation. DESIGN: Survey. SETTING: Station-based PPEs for area high school student athletes were performed using the form developed by the Preparticipation Physical Evaluation Task Force (PPETF). PARTICIPANTS: High school student athletes and their parents or guardians. MAIN OUTCOME MEASURES: The discrepancy rate (and associated clinical areas of those discrepancies) for information given by parent-student pairs completing a standard historical section of a PPE. RESULTS: Of the high school student athletes who participated in the station-based PPE, 111 (34%) participated in this study. These student athletes completed the PPE form (14 sections with a total of 38 specific questions) independently during an initial session, and then were given an identical PPE form that was completed with the assistance of a parent or legal guardian. Of the 111 parent-student pairs, only 22 (19.8%) histories were in complete agreement. Several questions had very poor agreement, as indicated by a kappa value < or = 0.4. Taken together, 4 of the 14 historical information sections found on the PPE (cardiovascular, neurologic, musculoskeletal, and questions pertaining to weight) accounted for 59% of all discrepancies. Answers to individual questions did not differ significantly between parents and students when analyzed together and then by gender and age. Interestingly, students answered significantly more questions in an affirmative manner than did their parents. CONCLUSION: Using the form developed by the PPETF, parents and student athletes may not provide reliable historical information on which to base participation decisions. In particular, unreliable information may be obtained regarding cardiovascular and musculoskeletal issues, areas that are related to the mortality and morbidity associated with athletic activity.

Adolescent↗
PubMed1999

Current concepts in the pharmacological management of obesity.

The pharmacological management of obesity has gained increasing attention as new weight loss treatments are approved and a significant proportion of the public strives to lose weight. Obesity is associated with a high mortality rate, multiple chronic medical conditions, and carries an enormous financial burden. Obesity is a multifactorial condition, most often due to an imbalance in energy intake and expenditure. Despite the greater focus on management of obesity, weight loss remains a difficult goal to achieve. Obesity is a chronic medical condition that may require long term treatment, therefore the risks and benefits of all pharmacological agents must be carefully considered. Noradrenergic appetite suppressants (ie. phenyl-propanolamine, phentermine) result in weight loss but stimulatory effects limit their use. The serotonergic agents (fenfluramine, dexfenfluramine) were effective weight loss drugs, but were voluntarily withdrawn from the US market last year because of cardiovascular and pulmonary complications. The combination noradrenergic/serotonergic agent sibutramine is indicated for the management of obesity, particularly in the presence of other cardiovascular risk factors. Modest weight loss is achieved with sibutramine, although weight gain is significant after discontinuation. In addition, long term safety data are not yet available. The thermogenic combination of ephedrine plus caffeine is minimally effective, and adverse effects are usually transient. Other thermogenic agents, such as beta3-agonists, are still under investigation. Agents may alter digestion through lipase inhibition (orlistat) or fat substitution (olestra). Orlistat decreases systemic absorption of dietary fat, decreasing body weight and cholesterol. Olestra is a fat substitute that has been incorporated into snack foods. Olestra substitution for dietary fat has not been studied as a weight loss strategy, although olestra has no caloric value and may be beneficial. The use of orlistat and olestra may be limited by gastrointestinal adverse effects. Finally, the manipulation of leptin and neuropeptide Y are under investigation for the treatment of obesity. Pharmacological agents should be used as an aid to a structured diet and exercise regimen in the treatment of obesity. Weight loss agents may result in initial weight loss, but sustained weight loss is not always achieved even with continuation of treatment. The effect of weight loss obtained while using pharmacotherapeutic agents on morbidity and mortality has not been established. Therefore, diet and exercise should be the focus of any weight loss programme. There is a continued need for safe and effective pharmacotherapeutic agents for the treatment of obesity.

Appetite Depressants↗
PubMed1999

Health care coverage of high school athletics in South Carolina: does school size make a difference?

Despite an apparently high injury rate, medical coverage available to these high school athletes is often not immediately present during practice and games. The purpose of the present study was to examine the current conditions of health care coverage and delivery to the football program and associated athletic departments in the public and private high schools in South Carolina. Additionally, the relationship between student enrollment and medical coverage was examined. A survey, based upon previously utilized instruments, was sent to the athletic directors at the public and private high schools with interscholastic football programs in South Carolina. The survey included questions pertaining to the medical coverage, including personnel, equipment, and record systems, for football practices and games. Based upon the results of the survey, a majority of high schools in South Carolina appear to have adequate sports medicine coverage and compare favorably with the results of similar data from other states. The medical coverage does significantly vary depending upon the enrollment size of the high school. In spite of this finding, the health care provided high school athletes is often inconsistent and training and equipment required for basic first aid is often absent.

Adolescent↗
PubMed1998

Rupture of pectoralis major during parallel bar dips: case report and review.

Rupture of the pectoralis major muscle is an uncommon athletic injury that can result in both functional and cosmetic deficiency. To date, most ruptures occurring in athletes have occurred while performing bench press or overhead lifting maneuvers. We describe a case of a pectoralis major rupture occurring while performing weighted parallel bar dips. Despite the popularity of this exercise, injuries associated with this exercise are infrequently reported. This injury can be easily detected by having the patient perform specific maneuvers on physical examination to accentuate any defect that may be present. In most cases, this injury is surgically repaired, although conservative treatment can be a successful option. Treatment options are discussed and recommendations given. A partial or complete tear of the pectoralis major muscle is a rare event and is often not easily detected on physical examination. Surgical repair is currently recommended to restore previous levels of strength and to correct the resulting cosmetic defect. Repair is rarely necessary to perform the normal activities of daily living.

Adult↗
PubMed1997

Management of obesity: medical treatment options.

Obesity is a common and serious health problem in the United States. Excess weight is associated with an increased mortality rate, as well as such risk factors as hypertension, hyperlipidemia and diabetes mellitus. Numerous treatments are available for obesity. Behavioral therapy, surgery and pharmacologic treatment have been used with varying degrees of success. Pharmacologic therapy includes primarily noradrenergic agents and/or serotonergic agents. Newer preparations are currently under development. Behavior modification, including regular exercise and the development of healthy eating habits remains the best hope for long-term weight loss. However, surgery or medication can be useful in specific circumstances.

Amphetamines↗