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Biomedical subjects

P J Collipp

Publications and source records attributed to P J Collipp.

At least 19 recordsLinked to original sources
PubMed1989

Effect of oral zinc supplements on diaper rash in normal infants.

A total of 89 normal newborn infants received 10mg oral zinc supplements daily for 4 months and 90 others received a placebo. The zinc supplemented group had a significant reduction in the incidence of diaper rash, and they gained slightly more in height and weight, although the growth differences were not significant.

Administration, Oral↗
PubMed1985

Hair zinc, scalp hair quantity, and diaper rash in normal infants.

Hair zinc concentration was determined by atomic absorption spectrophotometry in 308 normal newborn infants and 199 normal infants aged one to twelve months. Hair zinc concentration declined from 204 micrograms/gm at birth to 112 micrograms/gm at age eight months, and then rose to 144 micrograms/gm at age twelve months. Diaper rash was significantly associated with reduced hair zinc, and infants with the least hair had lower zinc levels than infants with the most hair. The data indicate that hair loss and diaper rash found in normal infants is significantly associated with a reduction in hair zinc concentration.

Diaper Rash↗
PubMed1979

Effect of growth hormone on lymphocyte respiration and growth rate of children.

Oxygen consumption by circulating lymphocytes of children with isolated growth hormone deficiency was studied before and 6 mo after the start of growth hormone therapy. A plot of percent change in respiration (oxygen consumed per mg protein or microgram DNA) against height gain during the therapy showed a linear association (correlation coefficient 0.667--0.756).

Adolescent↗
PubMed1976

Quenching of tryptophanyl fluorescence of human growth hormone by iodide.

Quenching of tryptophanyl fluorescence of human growth hormone by I- followed saturation kinetics and was abolished by KSCN. In the presence of 6 M guanidine hydrochloride quenching was linear between 0 to 0.2 M KI. These results suggest that I- quenched the fluorescence of the native hormone by binding at or near the single tryptophanyl residue. Quenching by 0.1 M KI decreased exponentially with increasing concentrations of human and bovine growth hormones. Acidification did not have a significant effect on quenching of the human hormone, but it markedly decreased quenching of the bovine hormone. Conformational differences at the vicinity of the lone tryptophanyl residue that could be inferred by these and other experiments may be contributing to the biological specificity of native human and bovine growth hormones.

Binding Sites↗
PubMed1976

Effect of growth hormone on weight and mitochondrial protein content of rat heart.

In male rats hypophysectomy reduced the wet weight of hearts per 100 g body weight. The yield of mitochondrial protein per g heart was also decreased which is in contrast to that in liver. Adiminstration of bGH to hypophysectomized rats reversed these changes towards normal. It appears that some of the effects of growth hormone may vary in different tissues.

Animals↗
PubMed1975

Pseudohypoparathyroidism with normal serum calcium level.

A mildly obese 15-year-old boy had short stature with rounded facies and short, stubby hands and toes. He had the fully expressed syndrome of pseudohypoparathyroidism but was the only member of his family who had all the somatic characteristics of this disease. The serum parathyroid hormone level was substantially elevated. Urinary excretion of cyclic adenosine monophosphate and phosphate failed to increase following intravenous infusion of parathyroid hormone. However, he did not have hypocalcemia. The present entity is probably a transient form of pseudohypoparathyroidism with partial responsiveness of skeletal adenyl cyclase to parathyroid hormone.

Adolescent↗
PubMed1975

Pyridoxine treatment of childhood bronchial asthma.

Urinary xanthurenic and kynurenic acid levels were measured in five patients while they were receiving 50 mg and 100 mg of pyridoxine. The levels of tryptophane metabolite decreased progressively as the dose was increased but remained above basal levels. There was marked clinical improvement in these patients while receiving the higher dose only. The double-blind study with 76 asthmatic children followed for five months indicated significant improvement in asthma following pyridoxine therapy (200 mg daily) and reduction in dosage of bronchodilators and cortisone. The data suggest that these children with severe bronchial asthma had a metabolic block in tryptophane metabolism, which was benefitted by long-term treatment with large doses of pyridoxine.

Adolescent↗
PubMed1975

Growth hormone and liver mitochondrial protein synthesis effect of cortisol and estradiol.

The effect of cortisol and estradiol on the stimulation by growth hormone of liver mitochondrial protein synthesis in hypophysectomized rats has been studied by measuring radioactive leucine incorporation in vivo and in vitro. Estradiol inhibited the stimulatory effect of growth hormone on incorporation into mitochondrial and microsomal proteins. Cortisol blocked the stimulatory effect of growth hormone on mitochondrial protein synthesis. The stimulatory effects of cortisol and growth hormone on microsomal incorporation were not additive. Gain in body weights corresponded with their effects on mitochondrial and microsomal protein synthesis. These results show that steroid hormones may act as regulators of the growth hormone effect.

Animals↗
PubMed1975

Tryptophane metabolism in bronchial asthma.

Seventeen out of 21 children with severe asthma had an abnormal increase in urinary Kynurenic (KA) and Xanthurenic (XA) acid following oral tryptophane administration. In a second study 11 asthmatic children had significantly greater increases in XA and KA than nine normal healthy children. A micro-assay of KA and XA by column chromatography was performed. The data suggest the presence of a partial block in the metabolism of tryptophane in some children with bronchial asthma.

Adolescent↗