Mental retardation in congenital hypothyroidism: improvement with thyroid replacement therapy.
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Child↗
Biomedical subjects
P J Collipp
Publications and source records attributed to P J Collipp.
Effect of potassium on human and rat liver glucose-6-phosphatase.
Potassium chloride concentrations of 100-150 mM were shown to inhibit (20-40%) human and rat liver microsomal glucose-6-phosphatase when the substrate was reduced to physiological concentration. When the enzyme was solubilized by treatment of microsomes with A12O3 the inhibition could be observed at greater substrate concentrations. Since potassium deprivation is associated with hyperglycemia in both animals and man, these observations may have physiological significance.
Aluminum↗
The effects of dietary zinc deficiency on voluntary alcohol drinking in rats.
The effects of dietary zinc deficiency on voluntary alcohol drinking in rats were examined in three separate experiments. Zinc-deficient rats showed a significantly greater voluntary alcohol intake as compared with the pair-fed controls. In the first experiment there were 14 male Sprague-Dawley rats with 7 controls and 7 who were begun on a zinc-deficient diet (below 2 ppm) at body weight 58-81 g. In the second experiment with 11 male Sprague-Dawley rats, the same diet was begun at 103-107 g. In the last experiment, 11 rats were begun at 120-199 g. Hair zinc measurements documented lower levels in the zinc-deficient rats after 6 weeks on the diet. The data indicate that a zinc-deficient state did increase voluntary alcohol intake in rats. In each experiment, the per cent alcohol consumed declined when a normal diet was given after the 6th week, and the difference was significant in experiments 1 and 3.
Alcohol Drinking↗
Red cell defects in Fanconi's anemia.
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Anemia, Aplastic↗