PubMed Health⌕ Search

Biomedical subjects

P J Cox

Publications and source records attributed to P J Cox.

At least 19 recordsLinked to original sources
PubMed1990

Midnight removal: an improved approach to removal of catheters.

There is no recognised policy regarding the timing of urethral catheter removal, although early morning removal is commonly practised. Removing the catheter at midnight allows patients to return to a normal voiding pattern more rapidly and to leave hospital earlier.

Female↗
PubMed1986

Towards no incisional hernias: lateral paramedian versus midline incisions.

A prospective randomized controlled clinical trial is reported which compares midline with lateral paramedian incisions in relation to the development of incisional hernias at one year. Of 431 patients randomized, 329 were available for assessment one year later. Two patients suffered burst abdomen, both being in the lateral paramedian group. Twenty-two incisional hernias occurred, 2 in the lateral paramedian group and 20 in the midline group (P less than 0.001). Of the two types of incision, the lateral paramedian incision takes longer to perform, requires a longer incision, rarely results in dehiscence, and does confer protection against incisional hernia.

Adolescent↗
PubMed1985

Host regulation of MOPC 104E plasmacytoma after reduction of tumor burden by total body irradiation.

Radiation-sensitive BALB/c MOPC 104E plasmacytoma was studied to investigate the effectiveness of total body irradiation in reducing tumor burden and preventing tumor regrowth. Also noted were the effects of such radiation on host immunity. BALB/c mice bearing 7-day-old occult tumors were not rendered free of disease when treated with radiation of 300 or 500 rad. However, all of the mice treated with 800 rad were cured. When mice bearing large tumors (24-days-old) were similarly treated, no cures were observed in the group treated with 300 rad. Of mice treated with 500 rad, 44% were cured, as were 100% given 800 rad of treatment. The percent reduction in serum MOPC 104E IgM increased with increasing radiation doses for the "large tumor" group. These observations show that total body irradiation may result in tumor elimination in an experimental animal multiple myeloma model. At lower radiation doses, host immunity appears to play an important role in achieving cure.

Animals↗
PubMed1984

Infectious bovine keratoconjunctivitis: isolation of Moraxella bovis from two groups of young beef cattle in fly control field trials during 1981.

The rate of infection with Moraxella bovis was determined for two herds of calves during the course of a year. High infection rates with the haemolytic variant were found in the herds while they were housed during their first winter but this infection rate fell steadily after turnout. A rise in infections with the non-haemolytic variant was observed during this time. The animals remained free from clinical infectious bovine keratoconjunctivitis during the summer, unlike similar groups of animals in previous years. Immunity, weather and flies are considered for their possible relevance to this observation.

Animals↗
PubMed1984

Tumor inhibitory triazenes. 3. Dealkylation within an homologous series and its relation to antitumor activity.

The in vivo antitumor activity and in vitro metabolic dealkylation have been measured for an homologous series of 3-alkyl-1-(4-carbamoylphenyl)-3-methyltriazenes and have been compared with their partition coefficients. This investigation has shown that the extent of oxidative metabolism in vitro and the antitumor activity in vivo of these compounds are dependent upon hydrophobicity. These findings provide confirmation for the relationship between metabolism and antitumor activity for aryldialkyltriazenes.

Animals↗
PubMed1984

Serum creatine kinase studies in mandibular pain dysfunction.

A biochemical test for muscle damage (serum creatine kinase estimation) was used to investigate twenty-six normal subjects, nine normal subjects following experimental bruxism and twenty-seven patients suffering from mandibular pain dysfunction. No significant differences in serum creatine kinase levels were detected between any of the groups.

Adolescent↗
PubMed1984

Breast problems in 1,000 consecutive referrals to surgical out-patients.

One-thousand consecutive referrals of breast complaints to surgical out-patients are presented with breakdown according to the pathological groups of final diagnoses. The relationship of these groups to parity, breast feeding and age are discussed as also is the clinical management of these cases.

Adolescent↗
PubMed1984

The metabolism in animals and man of oxmetidine--a new histamine H2-receptor antagonist.

The absorption, distribution, metabolism and excretion of [14C]oxmetidine in rat, dog and man has been studied following both i.v. and oral administration. Excretion is rapid and essentially complete in all three species. The biliary route is predominant. Distribution of radioactivity is widespread although none is seen in the brain. Metabolite patterns in urine from rat, dog and man have been compared by thin-layer chromatography. Metabolite patterns in urine and bile from rat and dog have been compared by high pressure liquid chromatography. Six major metabolites have been isolated and identified including two O-glucuronides and one N-glucuronide.

Absorption↗
PubMed1984

Inhibition of growth of MOPC 104E cells in immunosuppressed mice.

In this report we provide evidence that suggests that MOPC 104E may come under regulation in highly immunosuppressed hosts depleted of T cells. Mice that are adult thymectomized, total body irradiated, and transplanted with bone marrow cells were able to resist the growth of MOPC 104E cells. Spleen cells from such animals had low NK activity and no cytotoxicity against MOPC 104E, and poor response to Con A, PHA, and LPS. The animals were deficient in Lyt-1+ and Lyt-2+ cells. The growth of MOPC 104E cells was measured by using the circulating level of MOPC 104E IgM in vivo in mice treated by different modalities. We observed that inhibition of tumor growth in vivo varied with the treatment of the host. Growth was inhibited in the host in the following order: ATXBM greater than XBM greater than NORMAL greater than ATx mice.

Animals↗
PubMed1982

Burst abdomen and incisional hernia: a prospective study of 1129 major laparotomies.

Burst abdomen and incisional herniation are continuing problems for the general surgeon. A prospective study was carried out to define the extent of the problem. Over five years from 1975 to 1980 a total of 1129 major laparotomy wounds in adults were assessed at regular intervals for 12 months after operation. There were 19 burst abdomens (1.7%) and 84 incisional hernias (7.4%). The introduction of the mass-closure technique reduced the incidence of burst abdomen from over 3% in 1975 to 0.95% in 1979. It did not, however, improve the rate for incisional hernias, which was 7.6% in 1979. Many factors are associated with incisional herniation: old age, male sex, obesity, bowel surgery, type of suture, chest infection, abdominal distension, and, most important, wound infection. More work is needed to find the ideal method of wound closure, and efforts should be made to eliminate wound infection.

Female↗