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Biomedical subjects

P J English

Publications and source records attributed to P J English.

12 recordsLinked to original sources
PubMed1992

Survey of services and practices of cleft palate-craniofacial teams.

Questionnaire data about services and practices of cleft palate-craniofacial teams were obtained from 63 teams in 35 states. Findings indicate the following: (1) research was the least frequently conducted activity, although 73 percent of the teams indicated that they conducted research; and (2) the majority of those responding regarded cinefluoroscopy, endoscopy, perceptual assessment, oral examination, and videoendoscopy as important procedures, yet most patients (90%) seen by these teams did not receive instrumental assessment of velopharyngeal function.

Attitude↗
PubMed1988

Videourodynamic assessment of the Stamey procedure for stress incontinence.

Fifty-three patients underwent the Stamey procedure after stress incontinence was demonstrated by videourodynamic assessment. It was possible to repeat this assessment in 45 patients post-operatively; 58% were shown to be continent and in 20% the leakage was less. Failed operations were unrelated to age, weight, parity, degree of bladder neck descent or previous pelvic surgery. Coexisting detrusor instability was not a contraindication to surgery. Delayed voiding was common immediately after surgery but voiding problems were not encountered once micturition had been re-established. Although a significant objective failure rate was demonstrated, the Stamey procedure has many advantages and it can be recommended as first-line treatment in cases of stress incontinence.

Adult↗
PubMed1987

Modified method of diuresis renography for the assessment of equivocal pelviureteric junction obstruction.

Thirty-five hydronephrotic kidneys, in which diuresis renography showed either an equivocal (13) or non-obstructive (22) response pattern, were studied by a modified method in which intravenous frusemide was given 15 min before the start of the renogram so as to assess elimination during the period of maximum diuresis. Thirteen kidneys were identified as obstructed, including three in which the standard diuretic renogram appeared to exclude obstruction. These results indicate that the modified method increases the specificity of diuresis renography when used to assess patients with equivocal pelviureteric junction obstruction.

Adolescent↗
PubMed1986

Intravesical chemotherapy: in vitro studies on the relationship between dose and cytotoxicity.

The relative importance of two variables, drug concentration and period of exposure, in relation to the therapeutic potential of intravesical chemotherapy was examined in an experimental system. A human bladder cancer cell line was exposed to a range of concentrations of the four drugs commonly used to treat superficial bladder cancer (adriamycin, epodyl, mitomycin-c, thiotepa) for periods of 30, 60 and 120 min. An exponential relationship was observed between clonogenic cell kill and both drug concentration and period of exposure. Thus, under the experimental conditions employed, cytotoxicity is proportional to dose (i.e. concentration X period of exposure). These two variables are of equal importance in relation to tumor cell kill, indicating that maximum therapeutic benefit may be obtained by using the highest concentration achievable for as long as the patient can retain the instillate, bearing in mind the potential increase in toxicity to the patient and the cost.

Antineoplastic Agents↗
PubMed1984

The aetiology and management of acute epididymitis.

The aetiology of acute epididymitis presenting to a surgical unit in a District General Hospital is presented. Patients over 45 years old frequently have a coliform urinary tract infection which may be associated with bladder neck obstruction. These patients require treatment with a suitable antibiotic (Co-trimoxazole) and further investigation. This condition occurs more commonly in patients under 45 years old in whom it is not associated with urinary tract infection. We have not demonstrated significant chlamydial infection and in a double blind study the antibiotic Co-trimoxazole did not hasten recovery. In this group the aetiology remains obscure.

Acute Disease↗