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Biomedical subjects

P J Fultz

Publications and source records attributed to P J Fultz.

At least 19 recordsLinked to original sources
PubMed1999

Ovarian cancer: comparison of observer performance for four methods of interpreting CT scans.

PURPOSE: To assess the effects of four interpretative methods on observers' mean sensitivity and specificity by using computed tomography (CT) of ovarian carcinoma as a model. MATERIALS AND METHODS: CT scans in 98 patients with ovarian carcinoma and 49 women who were disease free were retrospectively reviewed by four experienced blinded radiologists to compare single-observer reading, single-observer reading with an anatomic checklist, paired-observer reading (simultaneous double reading), and replicated reading (combination of two independent readings). Confidence level scoring was used to identify three possible disease forms in each patient: extranodal tumor, lymphadenopathy, and ascites. Patient conditions were then categorized as abnormal or normal. RESULTS: There were no significant improvements in sensitivity or specificity for classification of patient conditions as abnormal or normal when comparing single-observer interpretation with single-observer interpretation with a checklist or paired-observer interpretation. Although there was no significant improvement in the mean sensitivity (93% vs 94%) by using the replicated reading method, there was a statistically significant improvement in mean specificity (85% vs 79%) for the replicated readings compared with single-observer interpretations (P < .05). CONCLUSION: Diagnostic aids such as checklists and paired simultaneous readings did not lead to an improved mean observer performance for experienced readers. However, an increase in the mean specificity occurred with replicated readings.

Female↗
PubMed1998

Nontraumatic rupture of the thoracic aorta: chest radiographic features of an often unrecognized condition.

OBJECTIVE: The purpose of our study was to evaluate chest radiographic features of nontraumatic mediastinal hemorrhage occurring after extrapericardial thoracic aorta rupture. MATERIALS AND METHODS: Twenty-seven consecutive chest radiographs obtained at admission of patients with hemorrhage from ruptured thoracic aorta aneurysms, aortic dissections, or penetrating aortic ulcers were randomized with radiographs of 23 subjects with nonruptured thoracic aorta aneurysms, 20 subjects with nonruptured dissections, and 20 control subjects. Diagnoses were established by interpreting CT scans, MR images, and findings at surgery or autopsy or both. A retrospective review was performed by three independent radiologists who were unaware of patients' diagnoses. Observers assessed 20 parameters on each of these 90 radiographs and summarized their findings with final diagnoses. The 20 parameters were analyzed with logistic regression and rank correlation to determine the best predictors of hemorrhage. RESULTS: Logistic regression analysis showed a combination of obscuration or convexity of the aorticopulmonary window and a displaced left paraspinal interface to be the most useful predictor of hemorrhage (p < .05). Rank correlation analysis indicated obscuration or convexity of the aorticopulmonary window; a displaced left paraspinal interface; enlarged aortic knob width; enlarged thoracic aorta size; an enlarged, obscured, or irregular aortic margin; and left pleural or extrapleural space fluid were potential individual predictors of hemorrhage (p < .05). Observer sensitivities for recognizing hemorrhage were 30-59% and specificities were 83-91%. Sensitivities for distinguishing an abnormal (n = 70) from a normal (n = 20) mediastinum were 79-90% and specificities were 65-90%. CONCLUSION: Obscuration or convexity of the aorticopulmonary window and a displaced left paraspinal interface on radiographs may indicate mediastinal hemorrhage. Further imaging is required to establish a definitive diagnosis.

Adult↗
PubMed1998

Extravisceral masses in the peritoneal cavity: sonographically guided biopsies in 52 patients.

OBJECTIVE: Our objective was to determine the effectiveness of sonographically guided biopsies of extravisceral masses (masses outside the solid organs) in the peritoneal cavity. MATERIALS AND METHODS: We retrospectively reviewed the results of sonographically guided biopsies of extravisceral masses found in the peritoneal cavity of 52 patients (age range, 25-90 years old; mean age, 52 years) from June 1990 to December 1996. Fifty-one patients underwent biopsy through the abdominal wall, and one patient underwent transvaginal biopsy. Sonographic guidance was obtained using 3.5- to 7.0-MHz vector probes. The size, depth, and sonographic characteristics of the mass and the type of biopsy (aspirate versus core) were determined for all lesions. Pathology reports and clinical courses were reviewed. RESULTS: Placement of the biopsy needle within the lesion was successful in all patients. The mean depth from skin surface to lesion was significantly less (p < .0001) when shown by sonography (2.4 cm) than when shown by CT (3.8 cm). Biopsy results were true-positive for malignancy in 37 patients (no false-positives), true-negative for benign masses in 10 patients, and false-negative for malignancy in three patients (sensitivity, 93%; specificity, 100%; accuracy, 94%). Nondiagnostic samples were obtained in two patients (4%). Treatment was based on diagnostic biopsy results in 43 patients (86%). CONCLUSION: Sonography is an effective alternative to CT in guiding biopsy of extravisceral masses in the peritoneal cavity.

Biopsy, Needle↗
PubMed1997

Magnetic resonance imaging appearance of fibromatosis colli.

We report the magnetic resonance imaging findings in a patient with fibromatosis colli, typically a self-limiting process that does not require therapeutic intervention. Familiarity with this condition and its appearance may prevent unnecessary invasive procedures.

Biopsy, Needle↗
PubMed1997

Radiologic consultation: effect on inpatient diagnostic imaging evaluation in a teaching hospital.

RATIONALE AND OBJECTIVES: The authors evaluated radiologic consultation affecting resident physician ordering of relatively expensive imaging studies. METHODS: Requisitions (n = 180) for expensive imaging studies from three general medicine floors (two consultation floors, one control floor) were prospectively evaluated. Information on the requisitions was classified as appropriate, inappropriate, or undecided if insufficient information was provided. On the consultation floors, but not the control floor, the medical residents were contacted about all studies initially considered inappropriate or undecided before they were performed. RESULTS: Nine of 119 requisitions (7.6%) from the consultation floors were considered inappropriate. In three studies (2.5%) the imaging evaluation was modified as the result of the interaction with the radiologist. There was no significant difference in the total number of radiologic studies or percentage of the total that were expensive imaging studies when comparing the consultation floors with the control floor. CONCLUSION: Radiologic consultation on expensive imaging studies through routine review of requisitions did not significantly change their use by house staff.

Diagnostic Imaging↗
PubMed1997

Interobserver and intraobserver variation in determining intrarenal parameters by Doppler sonography.

OBJECTIVE: This study identified the extent of inter- and intraobserver variation in assessing intrarenal Doppler waveform parameters. SUBJECTS AND METHODS: Optimized Doppler waveforms from the interlobar arteries of five healthy volunteers were recorded. The waveforms were digitized for off-line evaluation by six observers. Using the same set of waveforms, the observers initially selected three of six waveforms for each subject on the basis of their preference for clinical usefulness. The observers then were directed to evaluate three previously picked waveforms. The systolic acceleration time (SAT) and the resistive index were calculated from each waveform. The observers also characterized the shape of each waveform according to four categories. RESULTS: Significant interobserver (p < .01) but not intraobserver variation occurred when measuring the SAT. Differences were caused by the observers' perceptions of waveform shapes (kappa = .12, p < .01) as well as the observers choosing different systolic starting points. No significant inter- or intraobserver variation occurred in measuring the resistive index. CONCLUSION: Much variability among and within laboratories can be expected when observers of Doppler waveforms use SAT to evaluate patients for renal artery stenosis.

Adult↗
PubMed1997

Sonographic guidance of mediastinal biopsy: an effective alternative to CT guidance.

OBJECTIVE: Our objective was to determine the diagnostic and cost efficacy of sonographically guided mediastinal biopsy as an alternative to CT-guided mediastinal biopsy and to review our biopsy triage experience in switching from CT to sonography. CONCLUSION: Sonography is as safe and accurate as CT and is 25% less costly than CT. Sonography proved particularly valuable for identifying vessels and perfused tissue and for permitting upright biopsy positions in dyspneic patients. When using our triage criteria, radiologists should find sonographically guided mediastinal biopsy to be an attractive alternative to CT-guided mediastinal biopsy in most patients.

Biopsy, Needle↗
PubMed1997

Effective ultrasonographically guided intervention for diagnosis of musculoskeletal lesions.

Current algorithms recommend computed tomography or fluoroscopic guidance rather than ultrasonography for musculoskeletal intervention. We analyzed our ultrasonographically guided experience to evaluate its efficacy. Forty-seven patients underwent needle aspirates or biopsies or both in 13 extremity and 34 axial locations for 12 inflammatory lesions, 23 soft tissue masses, and 12 lesions arising from bone. Four lesions were initially imaged by ultrasonography; the remaining lesions were identified by computed tomography (25) or magnetic resonance imaging (18). Forty-six samples were diagnostic; one needle aspirate of an inflammatory mass yielded no diagnostic material. No complications occurred. Ultrasonographically guided musculoskeletal aspiration and biopsy are diagnostic and effective throughout the body, and with appropriate lesion access, they should be considered as an alternative to computed tomographic-guided procedures.

Adolescent↗
PubMed1996

Interstitial pregnancy complicated by rectal bleeding.

An interstitial pregnancy complicated by rectal bleeding is described. Despite modern imaging modalities, confounding features made preoperative diagnosis difficult. The pregnancy ruptured into the ileum. Ossified fetal skull bones and degenerated placental tissue were the only remains from the pregnancy.

Adult↗
PubMed1996

The prostate: decreasing cost-effectiveness of biopsy with advancing age.

RATIONALE AND OBJECTIVES: The purpose of this study was to determine the cost-effectiveness of prostate biopsy at different excess prostate-specific antigen (PSA) levels as a function of age. METHODS: Medical decision analysis was performed with standard software (SMLTREE) to determine marginal effectiveness in quality adjusted life years (QALYs) and marginal cost-effectiveness in dollars per QALY of immediate prostate biopsy at different excess PSA levels between 0 ng/mL and 20 ng/mL. The probability of clinically significant cancer with a positive biopsy (pD+Bx+) was assumed to decrease with age from 1.0 at age 50 to 0.2 at age 70. Costs were based on charges at our hospital and were considered over a 2-year time frame. RESULTS: With our base case assumptions there was a decrease in QALYs and an increase in costs doing an immediate prostate biopsy at all excess PSA levels between 0 ng/mL and 20 ng/mL, compared with not biopsying the prostate at > or = 70 years. Doubling pD+Bx+ from 0.2 to 0.4 in the 70-and-older age group resulted in a small increase in QALYs in biopsying the prostate at excess PSA levels between 0 ng/mL and 20 ng/mL. However, the marginal cost-effectiveness of prostate biopsy was very high, ranging from $275,000/QALY biopsying at an excess PSA level of 0 ng/mL to $68,000/QALY biopsying at an excess PSA level of 20 ng/mL. This compared with it being more effective and less costly to biopsy at all excess PSA levels > or = 0 ng/mL in 50-year old patients. CONCLUSION: Immediate prostate biopsy is not cost-effective and can be detrimental in patients > or = 70 years of age at all excess PSA levels between 0 ng/mL and 20 ng/mL.

Aged↗
PubMed1995

Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells.

BACKGROUND: Primary lymphoma of bone is a rare, aggressive neoplasm that can present with a large, soft-tissue mass despite minimal evidence of cortical destruction on plain radiographs. METHODS: High resolution magnetic resonance imaging (MRI) examinations of four patients with primary lymphoma of bone were reviewed retrospectively, and in each case intramedullary tumors demonstrated "penetrating channels" extending through the cortex. The MRI studies were correlated with the histopathologic assessment of the tumor for each patient. Immunohistochemistry was performed for immunophenotyping and for cytokine expression by tumor cells. The cytokines that were investigated were interleukin-1, interleukin-6, and tumor necrosis factor-alpha, molecules known to regulate osteoclastic activity. RESULTS: The linear cortical foci noted on MRI correlated with the histopathologic findings of tumor-associated cutting cones, in proximity to osteoclastic bone resorption. Immunohistochemical stains showed a B-cell phenotype for each tumor and positive immunoreactivity in tumor cells for cytokine mediators that stimulate osteoclastic activation. CONCLUSIONS: These findings indicate that the tumor cells in these cases produce soluble cytokine mediators that may regulate extensive osteoclastic activity. In primary lymphoma of bone, tumor activation of osteoclastic resorption, with production of tumor tunnels through the cortex, may represent one of the mechanisms by which lymphoma escapes the intramedullary space and forms large, soft-tissue masses without extensive cortical destruction.

Adult↗
PubMed1995

An additional imaging sign preceding spontaneous fragmentation and embolization of an implanted subclavian vein catheter.

Analysis of chest roentgenograms performed before spontaneous fragmentation and distal embolization of an implanted subclavian vein catheter revealed discontinuity of the catheter's radiopaque marker in addition to kinking of the area proximal to the breakage point. To the authors' knowledge the case presented in this article is the first report of this imaging sign before catheter fragmentation. Lateral catheter placement and early recognition of subtle imaging signs may assist in decreasing the incidence of this significant complication.

Catheterization, Central Venous↗
PubMed1995

Hepatic cysticercosis. Report of an unusual case.

We report a case of hepatic cysticercosis in a 62-year-old man who had been diagnosed with a colonic adenocarcinoma 9 years previously. Additional clinical studies failed to show disease in the soft tissues, brain, orbit and heart. The patient was successfully treated with a course of praziquantel and prednisone and is alive and well 28 months after diagnosis. This is the first reported case of hepatic cysticercosis that has resulted in significant morbidity.

Adenocarcinoma↗