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Biomedical subjects

P J Hall

Publications and source records attributed to P J Hall.

6 recordsLinked to original sources
PubMed1979

An in vitro study of the effects of calcium on the cardiovascular actions of thiopentone, althesin and ketamine in the rat.

The actions of three intravenous anaesthetics, Althesin, thiopentone and ketamine have been compared on the rat isolated atria and portal vein. Although the three anaesthetics had grossly similar actions on the two preparations. i.e. depression of atrial rate and depression of the amplitude of myogenic activity in the portal vein, there were enough differences to suggest that they produced their effects by different mechanisms. These differences were particularly obvious in interactions with noradrenaline and the effects of changes in calcium ion concentration on the concentration effect relationships for the agents on the atria and portal vein. Generally Althesin was unaffected by changes, but in qualitatively different ways.

Alfaxalone Alfadolone Mixture↗
PubMed1979

Lone aortic regurgitation, sacroiliitis, and HLA B27. Case history and frequency of association.

An account of aortic regurgitation complicating ankylosing spondylitis is given. Twenty patients with lone aortic regurgitation and without overt spondylitis were examined clinically and radiologically and tissue typed. No evidence of sacroiliitis could be found in any patient. HLA B27 was absent from this group, and no significant disturbance in antigen frequency was noted.

Adolescent↗
PubMed1978

Pesticin-dependent generation of somotically stable spheroplast-like structures.

Homogenous pesticin, a bacteriocin produced by Yersinia pestis, promoted rapid dose-dependent killing of Escherichia coli phi but permitted residual generation of cell mass. Both growing cells and those blocked in net synthesis of nucleic acids or protein were converted by pesticin to osmotically stable spheroplast-like forms. Morphology and viability of cells starved for fermentable carbohydrate were not affected by pesticin. Similar spheroplast-like structures were formed from sensitive cells of Yersinia pseudotuberculosis, Yersinia enterocolitica, and Y. pestis.

Bacterial Proteins↗
PubMed1976

Precipitating antibody response to malarial S-antigens.

The gel diffusion test has been used to detect antibodies to malarial S-antigens. Sera were obtained from entire Gambian village communities, from young children with acute P. falciparum malaria, from children convalescent from such infections and from immune adults. In community studies, small selections of S-antigens detected antibody frequently in sera from older persons but rarely in sera from young children. Larger panels of antigens detected antibodies in sera from half of 50 malarious children while homologous antibody responses were observed in 22% of 267 children followed at intervals during convalescence from malaria. In these latter cases, antibody tended to appear more swiftly when antigen was lost rapidly from the circulation, and observations made on individual responses indicated that antibody production was influenced by factors other than the intrinsic properties of the antigens. In adult sera antibodies usually occurred in association with IgG.

Adolescent↗
PubMed1975

Persistence and recurrence of S-antigen in Plasmodium falciparum infections in man.

The persistence of heat stable malarial antigens (S-antigens) in the sera of Gambian children following treatment for severe Plasmodium falciparum infections was investigated. In most cases S-antigens ceased to be demonstrable within 7 days but in some they were detected for several weeks and their persistence correlated with both the density of parasitaemia and the antigen titre observed before treatment. An exponential loss of circulating antigen was, in the majority of individuals, accelerated by some other factor which might have been homologous antibody. Renewal of asexual parasitaemia usually resulted in reduction in the rate of antigen loss or in an increase in antigen level. When the aparasitaemic interval was a month or less the antigens associated with different parasitaemic episodes usually showed identical specificities; when the interval was longer they were usually antigenically distinct. These findings may indicate that relapse parasites usually show the same S-antigen specificities as their progenitors while parasites arising from distinct infections tend to show different specificities and could therefore support a view that considerable antigenic heterogeneity exists among the parasites that comprise P. falciparum populations in endemic areas.

Antigens↗