The changing epidemiology of Ross River virus disease in South Australia.
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Alphavirus Infections↗
Biomedical subjects
P J Keary
Publications and source records attributed to P J Keary.
Determination of cytosine arabinoside in human plasma by high-pressure liquid chromatography.
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Chromatography, High Pressure Liquid↗
Benign self-limiting sarcoidosis with skin and joint involvement.
Three cases of sarcoidosis presenting with both erythema nodosum and erythema diffusion as well as with an arthritis and pulmonary involvement are described. The simultaneous occurrence of nodose and diffuse skin lesions would suggest that a clinical distinction between Lofgren's syndrome (Lofgren, 1953) and the syndrome described by Caplan, Katz, Rubenstein (1970) is not justified.
Adult↗
Pharmacokinetics of lithium: elimination half-time, renal clearance and apparent volume of distribution in schizophrenia.
The elimination half-time and renal clearance of lithium was measured in 12 schizophrenic patients. Minimum plasma lithium concentrations during alternate dosage intervals in 5 patients increased rapidly during the first 2 to 3 days of treatment and reached a steady state level after 5 to 6 days. After the establishment of the remaining 7 patients on lithium the decline in plasma lithium concentration when treatment was stopped was monoexponential. Elimination half-times ranged from 19.3 to 41.3 hours (mean +/- SD = 28.9 +/- 7.9h) and were significantly correlated with renal creatinine clearance (p less than 0.01). Renal lithium clearances ranged from 13.5 to 36.8 ml/min (mean +/- SD = 24.4 +/- 8.0 ml/min) and the apparent volumes of distribution ranged from 0.39 to 1.39 L/kg (mean +/- SD = 0.79 +/- 0.34 L/kg). There was no evidence that the elimination parameters of lithium in schizophrenic patients were significantly different from those in healthy individuals or manic-depressive patients.
Adult↗