Biomedical subjects
Publications and source records attributed to P J Lespi.
Bruner's gland hyperplasia (BGH) is an infrequent benign injury located on the first or second portion of the duodenum. We presented the case of a 59 year-old man with vomits, diarrhea, upper gastrointestinal bleeding intermittent and loss of weight in which was a nodule in the duodenum that corresponded to an hyperplasia nodular of Brunner's gland.
The histologic features of regression may be found in some basal cell carcinomas (BCCs), and it is known that T-cell infiltrates have a significant role in host defense against this tumor. We examined 945 hair follicles (HFs) adjacent to 150 regressing BCCs of skin for the presence of inflammatory infiltrates and compared the results against 315 HFs in 50 samples of normal skin. Focal T-cell infiltrates localized mainly to the upper portion of the HFs were found in 14.5% of the follicles adjacent to regressing BCCs. A statistically significant increase of inflammation in HFs was observed in BCCs with active regression compared with BCCs with inactive and mixed regression (P < 0.05). An increase in the number of HFs involved by T lymphocytes was also found in regressing BCCs compared to normal skin ( P < 0.00005). These data suggest that the damage to the follicles is concordant with active regression of BCCs. We speculate that the immune-mediated regression of BCCs is not only specifically directed to the cells of the tumor but may also induce activated lymphocytes with cytotoxic capability to cross react with the follicular epithelium.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A case of xanthogranuloma of the stomach as cause of clinical signs of gastric cancer is reported. Review of the literature is also included.
The case of an eighty five year old woman with a polypoid hyperplasia of Brunner's glands as cause of digestive tract hemorrhage is reported.
Explore the source record for details and available documents.
Granular cell tumor of the esophagus, also called Abrikossof's tumor, is a rare and mostly benign neoplasm which is associated with cancer in 11% of cases reported in the literature. We report herein a 48 year-old-man with granular tumor of the esophagus and carcinoma of the papilla of Vater. it is a unreported association.
Endometrial carcinoma is rare in women under 40 years of age. The incidence in this age group has been variously reported to be from 1% to 8% of all cases of endometrial carcinoma. Women at high risk, as a result of excess estrogenic stimulation are those with polycystic ovaries, long-standing estrogen users and functioning granulosa cell tumors and thecomas. We report two cases of young women with endometrial carcinoma and polycystic ovaries (Stein-Leventhal syndrome).
We describe the case of a 70-year-old woman admitted to our hospital because of anemia and hepatomegaly. Imaging studies (ultrasound and CT scan) revealed a tumor in the liver. The patient developed consumption coagulopathy and died. Postmortem examination revealed hepatic angiosarcoma. The pathophysiology of disseminated intravascular coagulation associated with vascular tumors and abnormalities of blood coagulation in patients with cancer is discussed.