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Biomedical subjects

P J Lindop

Publications and source records attributed to P J Lindop.

At least 19 recordsLinked to original sources
PubMed1976

Some in vivo effects of pi mesons in mice.

The effect of 70 MeV pi mesons was studied to determine the effectivness of such beams aginst normal tissues in vivo. The end points included thymic weight loss, oocyte and bone marrow CFU-S survival and the induction of macroscopid lens opacities. The results indicate that pi mesons are not signifacantly more effective for these end-points than more conventional radiation sources such as 60Co gama rays, 220 kVp X rays, and 14 MeV X rays and electrons. Nor was there any detectable difference in RBE between the peak and plateau regions of the pi meson beam. The significance of these findings is discussed in relation of the the published pi meson RBE values of between 1 therefore 4 and 5 therefore 0.

Animals↗
PubMed1975

Studies on the humoral regulation of granulopoiesis in leukaemic RFM mice.

Intraperitoneal diffusion chambers have been used to investigate changes in humoral factors during the development of myeloid leukaemia in mice. Normal mouse bone marrow cells form colonies of granulocytes and macrophages when cultured in semi-solid agar medium within intraperitoneal diffusion chambers. The use of mice bearing transplanted myeloid leukaemia as Agar Diffusion Chamber (ADC) hosts enhances colony formation from normal marrow. The humoral basis for this stimulation has been shown by the colony stimulating activity of the fluid entering the diffusion chambers when assayed against normal mouse bone marrow cells in agar culture in vitro. The stimulus to colony growth in ADCs and the in vitro colony stimulating activity depend on the phase in the development of the leukaemia investigated, and the stimulation was abolished by splenectomy. There was no apparent relationship between the growth of the leukaemic cell population in vivo and the level of the stimulating factor detected in leukaemic mice.

Animals↗