Biomedical subjects
Publications and source records attributed to P J Milton.
Disopyramide (200 mg 8-hourly) was given to a pregnant patient from the 26th week onwards for the treatment of bigeminy and paroxysmal ventricular tachycardia. Labour was spontaneous and normal. Although disopyramide was demonstrated in the foetal blood there was no evidence of congenital abnormality or growth retardation. The drug treated the mother satisfactorily with no apparent ill effects to the child.
The oestrogen receptor from human myometrium has been extensively purified by affinity chromatography and isoelectric focusing. The latter step is necessary to remove contaminating sex-steroid-binding globulin. The unpurified 3.7-S cytoplasmic receptor has a molecular weight of 41,000, a Stokes radius of 27.0 A and a frictional ratio (f/f0) of 1.19; the KD (4 degrees C) for [3H]oestradiol-17 beta was 1.03 X 10(-10) M. After purification, the molecular weight was 30,000, the Stokes radius 23.6 A, frictional ratio 1.15 and isoelectric point 6.15.
A 19-year-old patient was treated for disgerminoma of the right ovary by right salpingo-oophorectomy and pelvic radiotherapy in 1967. The left ovary was shielded after the first two treatments and the patient has since conceived three times and has shown no evidence of recurrence of the tumour.
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