Biomedical subjects

P J Pye

Publications and source records attributed to P J Pye.

2 recordsLinked to original sources

PubMed2000

A practical synthesis of a COX-2-specific inhibitor.

A number of synthetic strategies to the Cox-2 specific inhibitor 1 have been described. These studies have led to the identification of a novel pyridine construction using annulation of ketone 2 using a vinamidinium species 29 and ammonia in 97% assay yield. Three approaches to the synthesis of ketone 2 are described that allow for its preparation in large quantities in >65% overall yield from methyl 6-methylnicotinate.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMedDate not supplied

Handicapped babies: how midwives cope.

Research into families with a handicapped child produces numerous examples of the inadequate ways medical personnel inform parents of their child's condition. In the case of the abnormal neonate, midwives have a part to play in this communicating process; thus helping to lay the foundations for satisfactory adjustment by the parents. This paper suggests that midwives need more appropriate training in this important role.

Communication↗