It has been suggested that the serum phosphate level is significantly elevated early in massive intestinal infarction. We attempted to determine whether or not this elevation in serum phosphate level is indeed an early and reliable diagnostic finding and to define the relationship between this elevation, the re-establishment of mesenteric blood flow and the viability of the intestinal wall. Significant elevation in serum phosphate value occurred after four hours of ischemia. This was associated with irreversibility of the ischemic process and intestinal necrosis according to an intravenous fluorescein test and pathologic data. The results of other superior mesenteric artery-12 parameters followed were erratic and appeared to have no diagnostic value in acute mesenteric arterial occlusion. Significant serum phosphate level elevation occurs in arterial intestinal ischemia, but this is not an early diagnostic sign, becoming significant only after irreversible necrosis of the intestine.

Animals↗

PubMed1981

Peritoneal lavage with povidone-iodine solution in experimentally induced peritonitis.

Two experimental studies were carried out upon dogs to clarify the efficacy of peritoneal povidone-iodine lavage in peritonitis. With an experimental model of peritonitis which closely resembles the clinical situation, we found that peritoneal lavage with povidone-iodine was not more effective than other lavage regimens in decreasing bacterial colony counts and was associated with an early 100 per cent mortality. Renal function was not affected by the treatment with this antiseptic solution. However, we found a statistically significant superimposed metabolic acidosis in the peritonitis group treated with povidone-iodine when compared with the other groups, by means of a significant decrease in base excess, p less than 0.01, at the two hour postlavage measures. This metabolic acidosis was also observed in normal dogs undergoing peritoneal lavage with povidone-iodine, showing a significant decrease in serum bicarbonate level one hour, p less than 0.05, and three hours, p less than 0.01, three hours postlavage, when compared with a sham laparotomy group in the nonperitonitis study. This has not previously been experimentally investigated. In view of these results, we do not recommend the clinical use of povidone-iodine solution for peritoneal lavage in peritonitis.

Acidosis↗

PubMed1980

The technique of myotomy in esophageal reconstruction: an experimental study.

Circular myotomy has been shown to be a useful technique for approximating widely separated segments in esophageal atresia. We tested variations of this technique experimentally in dogs and found a significantly greater decrease in tension after double, spiral, and stepladder myotomies. Complications as measured by mortality and morbidity (leaks, strictures, and weight loss) were not found to differ statistically in the various groups, although there is a suggestion that the spiral myotomy group may have less postoperative problems.

Animals↗

PubMed1980