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P J Webb

Publications and source records attributed to P J Webb.

45 records · Page 3Linked to original sources
PubMed1980

A physiological study of elastic compression stockings in venous disorders of the leg.

The physiological effects of elastic compression stockings on venous disorders of the leg have been studied in three groups of 10 patients. These patients were divided by examination and ascending venography into those with: (a) a normal venous system in the leg, (b) superficial varicose veins and (c) a post-phlebitic limb. In a randomized cross-over trial each groups wore Eesiness NHS two-way stretch or Sigvaris medium compression below-knee stockings for three weeks. In the post-phlebitic limb group a further comparison was made with Sigvaris strong compression below-knee stockings after a 6-week rest period. The effects were objectively compared using foot volumetry and sodium (24Na) subcutaneous tissue clearance. The physiological benefits of Sigvaris medium and strong compression stockings were comprehensively demonstrated by both methods of assessment in patients with the post-phlebitic limb. Benefit from Sigvaris medium compression stockings was also demonstrated in the patients with varicose veins. In the group with normal veins there were negligible physiological benefits from compression stockings. Eesiness stockings failed to produce a significant physiological effect in each group.

Clothing↗
PubMed1980

The Monk "soft top" endoprosthesis. Clinical, biomechanical and histopathological observations.

This paper presents a prospective trial carried out using the Monk "soft top" endoprosthesis in 33 patients. Two years after operation 70 per cent of the remaining patients had pain. A biomechanical and histopathological analysis of the endoprosthesis and the surrounding tissue, obtained from a further two patients at the time of revision, is presented. It is concluded that the prosthesis has inherent design faults which result in excessive wear of the polyethylene component. The wear debris produced stimulates a prolific fibrous tissue reaction which is associated with progressive clinical deterioration.

Aged↗
PubMed1980

Quantitative studies of natural immunity to solid tumours in rats. The nature of the killer cell depends on the type of assay.

Cell fractionation techniques were used to identify the cells in rat spleen responsible for natural killing of a syngeneic sarcoma cell in short-term (6 h and 18 h) and long-term (72 h) cytotoxicity assays. Cytotoxicity was quantified precisely using a method previously derived from consideration of natural cytotoxicity as an enzyme-substrate reaction, and by analysing results in terms of lytic units. Killing in all three assays displayed 'single-hit' kinetics implying that a single effector cell was sufficient to lyse a single target cell. The fractionation studies, using glass adherence, carbonyl iron, nylon wool, EA and EAC monolayers and congenitally athymic rats, revealed two populations of cytotoxic cells. In the 6 h assay most of the activity was due to cells with similar characteristics to the NK cells previously defined using leukaemic targets, but in the 18 h and 72 h assays macrophages played an important rôle. The activity exerted by the macrophages was cell lysis and not cytostasis. No evidence that the macrophages acted by releasing factors which stimulated NK cells could be found.

Animals↗
PubMed1975

Hand table.

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Hand↗