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Biomedical subjects

P Janík

Publications and source records attributed to P Janík.

18 recordsLinked to original sources
PubMed1990

[Primary adenocarcinoma of the esophagus].

The presented analysis of a patient treated at the 1st Surgical Department of the Teaching Hospital in Bratislava meets the criteria for being classified as primary adenocarcinoma of the esophagus, whose characteristics are described in the paper. Primary adenocarcinomas of the esophagus occur rarely and constitute only about 0.5% of large series of esophageal malignancies. The tumor is not connected with the gastric mucosa, being separated from it by the normal mucosa of the esophagus, and it is not a metastasis. The patients suffer from late not marked dysphagia. The endoscopic and histologic findings are frequently misleading since the mucosa above the tumor is usually intact.

Adenocarcinoma↗
PubMed1990

[Resection of the subtalar joint--long-term results].

In the years 1965-1985 212 patients were treated at the I. Orthopaedic Clinic in Brno by means of the resection sub talo. 100 patients with 105 operations were checked up on average 13 years after operation. The average age in the time of operation was 27. Indicated for operation were in 54 cases patients with neurologic deformity of the foot, in 51 cases patients with a local deformity. Reported were 65 good, 25 fair and 15 poor results. Residual deformity occurred in 12 patients and severe instability of the leg also in 12 cases. Eight patients suffered from moderate arthrosis of the joint ankle, three patients had severe arthrosis. Pseudoarthrosis in the area of resection was found in 5 cases. Prior to operation it is inevitable to examine the stability of the talus and anterior subluxation of the ankle joint. In cases of the instability of the talus ankle arthrodesis is indicated. The authors put emphasis on the release of soft tissues prior to or during the operation. The work proves longterm usefulness of the resection sub talo.

Adult↗
PubMed1989

[Cardiac complication of mucoviscidosis].

Over the years 1971 to 1988 autopsies of 33 children with the clinical diagnosis of mucoviscidosis were performed at the Institute of Pathology, Medical Faculty, Comenius University, Bratislava. In three cases pronounced changes were observed on the myocardium, predominantly on the left ventricle. Multifocal necrosis and fibrosis of the myocardium represent rare but severe changes occurring as a complication of mucoviscidosis in infancy.

Child, Preschool↗
PubMed1989

[Myocardial damage as a rare complication of mucoviscidosis].

A postmortem examination was performed on a male child who had lived to twelve months of age, at the Institute of Pathology of the Medical Faculty of Comenius University in Bratislava, Czechoslovakia. The clinical diagnosis had been mucoviscidosis, bronchopneumonia, and dystrophy. Findings characteristic of cystic pancreas fibrosis and bronchopneumonia of the right lower lung lobe were macroscopically recorded and were microscopically established. Massive fibrotic and necrotic lesions were primarily recorded from the left cardiac ventricle and were considered to be unusual findings. Damage to the myocardium is a very rare complication of mucoviscidosis. Less than 50 cases have so far been described, according to Benesová et al. (1983).

Cardiomyopathies↗
PubMed1985

Effect of a low sodium medium, ouabain and noradrenaline on relaxation of the myocardium of the perfused rabbit heart.

Random stimulation of the perfused heart allows relationships between the rate of contractions (dP/dtmax), the size of contraction (Pmax) and the rate of relaxation (dP/dtmin) of contractions of varying intensity to be studied. The present study concerns these relationships during perfusion with ouabain, a low sodium medium and noradrenaline. Isolated rabbit hearts were perfused with Tyrode solution (O2 95%, CO2 5%, 36.4 degrees C), the isovolumic contractions of the left ventricle were recorded and the right ventricle was stimulated at random for 30 s (pulse width 10 ms, voltage double the threshold value). Perfusion was then switched over to perfusion with ouabain solution (10(-6) mol.l-1), with noradrenaline solution (10(-6) mol.l-1) or with low sodium solution (with 31% of the normal Na concentration). When spontaneous contraction size had attained a stable level, random stimulation was repeated. During random stimulation, dP/dtmin was directly proportional to Pmax (dP/dtmin = k1.P max) and to dP/dtmax (dP/dtmin = k2.dP/dtmax). Ouabain and low sodium did not change k1 or k2 and noradrenaline did not change k2. The increase in k1 during noradrenaline perfusion corresponds to shorter duration of contraction. It was found that dP/dtmax, which corresponds to the sarcoplasmic calcium concentration at the outset of activation, was the main factor determining the relaxation rate during ouabain, noradrenaline and low sodium perfusion.

Animals↗
PubMed1982

Relaxation of the myocardium of the perfused and ischaemic rabbit heart.

The decrease in the rate of relaxation of the myocardium during ischaemic impairment of metabolic processes is accompanied by a decrease in the size of contraction. If we stimulate the ischaemic heart with irregularly distributed pulses we can achieve, by an extrasystolic potentiation mechanism, isolated contractions. If we stimulate the ischaemic heart with irregularly distributed pulses we can achieve, by an extrasystolic potentiation mechanism, isolated contractions of the same size as average contractions in normal perfusion. When comparing the relaxation of such contractions in 15 perfused rabbit hearts, we found a linear correlation between the relaxation rate and the size of the contractions. If we relate to relaxation rate to contraction size, the relaxation rate in early ischaemia (1 min after stopping perfusion) is thus in most cases normal, despite the marked decrease in the size of the contractions. The size of the contractions of the ischaemic mammalian myocardium thus seems to diminish before relaxation (which is likewise energy-dependent) is affected.

Animals↗