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Biomedical subjects

P Jebavý

Publications and source records attributed to P Jebavý.

At least 37 records · Page 2Linked to original sources
PubMed1980

Pulmonary gas exchange after propranolol in patients with ischaemic heart disease.

Pulmonary gas exchange was evaluated after 10 mg i.v. propranolol in 12 patients 3-6 months after acute myocardial infarction undergoing haemodynamic examination in our outpatient department. None of them exhibited clinical signs of heart failure or obstructive airways disease. Routine spirometric examination was normal in all patients. Propranolol led to a distinct deterioration of LV function and to a fall in left ventricular filling pressure both at rest and during exercise. At rest, the administration of propranolol resulted only in a significant decrease of total ventilation. During exercise, its administration was followed by a significant decrease of the tidal volume, alveolar ventilation and VA/VE index. Arterial CO2 tension and physiological dead space ventilation increased significantly. Arterial oxygen tension decreased after propranolol insignificantly both at rest and during exercise. No patient reported dyspnoea after propranolol; 8 patients reported a decrease or disappearance of effort dyspnoea. None exhibited clinical signs of bronchospasm.

Adult↗
PubMed1980

Doppler echocardiography in diagnosis of mitral insufficiency.

By means of pulsed Doppler echocardiography (PDE) the authors investigated 53 patients who subsequently underwent heart catheterization and left ventriculography. The results of PDE examination agreed with ventriculography in 29 out of 31 patients with mitral regurgitation (PDE sensitivity = 94%). In 22 patients with no angiographic evidence of mitral regurgitation PDE exhibited two false positive results (PDE specificity = 91%). A semi-quantitative assessment of regurgitation by predetermined PDE criteria was successful in differentiating a group of severe mitral insufficiency (MI) from less significant MI (= mild and moderate MI angiographically). The agreement with ventriculographic classification of MI was 87 and 86%, respectively. The presented results clearly indicate that PDE, as a non-invasive methods, is precise enough in detecting mitral regurgitation and can be recommended for application in adult cardiology.

Doppler Effect↗
PubMed1979

The effect of propranolol on left ventricular function at rest and during exercise in patients with ischemic heart disease.

Twelve patients with ischemic heart disease were investigated by right and left heart catheterisation. All patients were studied at rest and during exercise, both before and after administration of beta-blocker propranolol, Inderal (ICI). Left ventricular function decreased after administration of propranolol, but these changes were significant only during exercise. Contractility was depressed after administration of propranolol already at rest. On the other hand, left ventricular filling pressure decreased after administration of propranolol. Our results show the poor reliability of the evaluation of the left ventricular function based solely on the left ventricular filling pressure.

Aged↗
PubMed1978

Influence of pulmonary hypertension on pulmonary diffusing capacity in patients with mitral stenosis.

The pulmonary diffusing capacity (DLCO--steady state method according to Bates and coworkers) was measured at the time of heart catheterization in 12 patients with mitral stenosis without mitral incompetence. DLCO correlates with the tidal volume at rest and during exercise and with pulmonary vascular resistance during exercise only. DLCO and left atrial pressure exhibit a positive correlation up to 22.5 mm Hg only. In patients with mitral stenosis DLCO depends on the alveolar surface area and DLCO is influenced by regional changes in the pulmonary vascular resistance.

Adult↗
PubMed1978

Pulmonary gas exchange in candidates for surgical treatment of ischaemic heart disease.

The spirometry and pulmonary gas exchange in 38 patients with ischaemic heart disease (IHD), selected for direct revascularization of the myocardium (or combined with left ventricular aneurysmectomy), were examined on the basis of clinical investigation and coronary arteriography. Elevated left ventricular end-diastolic pressure was found in 40% at rest and in more than 50% of patients during exercise. Vital capacity was entirely within the normal limits. A relation was found between the period of time since the first acute myocardial infarction. In 20% of the patients the forced expiratory volume was below the predicted normal, but the decrease was not significant. A mild arterial hypoxaemia was found in 64% of patients at rest and in 70% during exercise; 79% showed an elevated alveolar arterial oxygen gradient. The abnormalities did not depend on the degree of coronary artery and left ventricular involvement nor on the haemodynamic parameters. However, a certain relation to history of cigarette smoking, which appears to affect pulmonary gas exchange more than IHD, was observed. The degree of respiratory disturbance does not in any way influence the proposed surgical treatment.

Adult↗
PubMed1977

Relations of pulmonary diffusing capacity to ventilation and haemodynamics in healthy subjects.

The pulmonary diffusing capacity (DLCO) was measured in 13 healthy subjects during heart catheterization by the steady-state method (according to Bates and his coworkers). The DLCO shows the closest correlation to the tidal volume at rest, and to the central blood volume during exercise. Further, the DLCO correlates with the cardiac index both at rest and during exercise and with the stroke index at rest only. The DLCO did not show any relationship to the pressures in central circulation, pulmonary vascular resistance, total and alveolar ventilation. Statistical analysis shows that DLCO is most consistently related to the tidal volume at rest, whereas relation to central blood volume is much more stable during exercise.

Adolescent↗
PubMed1977

Left ventricular end-diastolic volume during supine exercise in patients with healed myocardial infarction.

Eighteen men with myocardial infarction in their history and without signs of heart failure were investigated at rest and during standard supine exercise. In nine patients aneurysma or diskinesis of the left ventricular wall were found. The left ventricular end-diastolic volume was determined from the wash-out of 133Xe injected into the left ventricle by means of precordial scintillation counting. During exercise the cardiac index rose owing to acceleration of the heart rate, whereas the stroke index remained unchanged, and the left ventricular work and stroke indices increased. The left ventricular end-diastolic pressure, elevated at rest, reached high values during exercise. The left ventricular end-diastolic and residual volumes decreased during exercise in most patients, and simultaneously the systolic ejection fraction increased. In patients with aneurysma or diskinesis the end-diastolic volume both at rest and during exercise does not differ from EDV of other patients. Six patients developed angina pectoris during exercise, but their haemodynamics did not differ significantly. It is concluded that the left ventricle in patients with advanced coronary heart disease and previous myocardial infarction shows the signs rather of diminished compliance than of heart failure during adequate exercise and still possesses some functional reserves.

Adult↗