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Biomedical subjects

P Jehan

Publications and source records attributed to P Jehan.

12 recordsLinked to original sources
PubMed1981

Obstructive jaundice in children with histiocytosis X.

Prolonged cholestasis was observed in 6 children with histiocytosis X. Operative cholangiograms confirmed the patency of the extrahepatic biliary tree and showed marked distortion of intrahepatic bile ducts resembling that observed in sclerosing cholangitis. Histologic examination showed portal fibrosis in all patients; only one was found to have portal histiocytic infiltration. The subsequent course confirmed the ominous significance of cholestasis in histiocytosis X, a rare finding in this disease: One patient died of progressive liver failure and three others from sepsis after unsuccessful attempts to improve the condition of the liver with chemotherapy.

Adolescent↗
PubMed1976

Histologic study of biliary fibrous remnants in 48 cases of extrahepatic biliary atresia: correlation with postoperative bile flow restoration.

The fibrous remnants of bile ducts that were removed at surgery for extrahepatic biliary atresia were studied by serial section. Forty-eight specimens were classified into three types on the basis of histopathologic changes in the proximal portions of the speciments from the vicinity of the porta hepatis: (1) connective tissue without glands or other epithelial structures (15 cases); (2) connective tissue containing glands lined with cuboidal epithelium (15 cases); (3) connective tissue containing central biliary ducts and peripheral glands (18 cases). Histopathologic changes in sections from distal portions of the specimens did not conform to this classification. A precise correlation of prognostic significance could not be established between these histologic data and postoperative restoration of bile flow, although failure to restore flow was encountered most frequently in cases without demonstrable ducts or glands (TYPE 1).

Bile↗
PubMed1975

[Laryngo-pharyngeal paralysis. Complications during the course of myelomeningoceles].

Report of 5 cases in babies with myèlomeningocele and hydrocephalus stridor and troubles in swallowing appeared after a free interval. These facts were already reported in literature. They represent an impairment of cranial nerves (IX,X and XI). The lesion may be located at the level of the nerves themselves or at the level of the origin nucleus in the brain stem. The mechanism of the lesion is not well known. The role of intracranial hypertension and of Arnold-Chiari malformation seem to be prominent.

Arnold-Chiari Malformation↗