PubMed Health⌕ Search

Biomedical subjects

P Jessen

Publications and source records attributed to P Jessen.

At least 19 recordsLinked to original sources
PubMed2001

[Coronary surgery of the beating heart. First year of experience in a series of 317 non-selected coronary patients].

From May 1999 to May 2000, 317 unselected patients, representing 92.7% of all coronary artery surgery procedures, underwent open heart surgery of the beating heart by median sternotomy with the aid of a cardiac stabilising device. The main preoperative characteristics were: mean age = 66.1 years; men = 78.9%; left main stem disease = 31.8%; mean left ventricular ejection fraction = 54.1%; mean Parsonnet index = 16.9. These 317 patients were compared with a group of 303 patients who underwent coronary bypass surgery the year before by the same surgical team with cardiopulmonary bypass (CPB) and cardiac standstill. Seven hundred and eighty-six distal anastomoses were carried out in the beating heart group (2.48 grafts per patient) compared with 2.91 in the CPB group: p < 0.001). There were 10.1% single bypass, 37.5% double bypass, 47.3% triple bypass and 5% quadruple bypass procedures. A cardiopulmonary bypass was required in 13 patients (4.1%). The mortality at 30 days was 3.1% versus 4.6% in the CPB group (p = NS). The need for blood transfusion was reduced by nearly 40% in the beating heart group (23.7% versus 39.9%, p < 0.001). The incidence of cerebrovascular complications was reduced from 3% in the CPB group to 0.6% in the beating heart group (p = 0.06). The peak postoperative troponine I levels were much lower in the beating heart group (2.5 versus 6.4 ng/ml, p < 0.001). The authors conclude that surgery on the beating heart is feasible in most patients. Compared with conventional surgery under CPB, there seems to be less requirement for blood transfusion and a tendency to reduce the cerebral risk. Nevertheless, a large prospective randomised trial is required to validate the potential advantages and limitations of this technique with respect to conventional surgery and to determine the optimal indications of surgery on the beating heart.

Adult↗
PubMed1992

[Granulocyte-macrophage colony-stimulating factor. Treatment of patients with highly malignant lymphomas and acute lymphoblastic leukemias after autologous bone marrow transplantation].

We have evaluated the effect of intravenous infusions of granulocyte-macrophage colony-stimulating factor (GM-CSF) in ten patients undergoing autologous bone marrow transplantation after total body irradiation (11 Gy) and cyclophosphamide (120 mg/kg) conditioning for malignant lymphomas or acute lymphoblastic leukaemias. Mild side effects related to GM-CSF were seen in six patients, of whom one chose to discontinue treatment. Compared to a historic control group consisting of six patients treated with an identical conditioning regimen, a tendency was seen towards a more rapid neutrophil regeneration and a decreased need for erythrocyte transfusions. Moreover, a statistically significant improvement in thrombocyte related parameters was demonstrated. In contrast, there were no significant differences in severe toxicity, days on i.v. antibiotics, septic episodes or duration of hospitalization. In conclusion, it seems that GM-CSF treatment is of value in patients undergoing AKMT.

Adolescent↗
PubMed1991

Regulation of autologous T-lymphocyte clones on in vitro growth of BFU-e: enhancing effects of both CD4- and CD8-positive clones.

In order to characterize the effect of T lymphocytes on the in vitro growth of erythroid progenitor cells (EPC), we have optimized an assay for evaluating the influence of autologous T-lymphocyte clones on BFU-e, grown from PBMNCs depleted of T lymphocytes. Testing a large number of T-lymphocyte clones from 2 individuals we found that, irrespective of immunological phenotype, all clones tested were found to enhance the growth of BFU-e. Thus, no evidence for a functional dichotomy between CD4+ and CD8+ T lymphocytes was found in this system. The enhancing effect worked across a histocompatibility barrier and was, at least in part, mediated by soluble factors. We therefore conclude that the role of the majority of cloned normal T lymphocytes in the regulation of the in vitro growth of EPC is a supportive one.

Antigens, CD↗
PubMed1985

Comparison of interval and postabortal/puerperal laparoscopic sterilization with the tubal ring procedure.

During a 5-year period, 344 women underwent laparoscopic sterilization with the tubal ring. Complications and failure rates were compared in intervals and postabortal/puerperal procedures. Only 9% were lost to follow-up, and 50% underwent a hysterosalpingoghraphy (HSG). The comparison of interval and postabortal/puerperal procedures showed no significant differences in complication rates, but postabortal/puerperal laparoscopy had a significantly lower failure rate than interval procedures (p less than 0.01). It was found that women whose laparoscopy was carried out despite peroperative complications had a significantly higher risk of sterilization failure (p less than 0.005). It is concluded that postabortal/puerperal laparoscopic sterilization with the tubal ring procedure is as safe as interval sterilization, and it is strongly recommended that peroperative complications with tubal ring sterilization should result in a reversion of the laparoscopy to a laparotomy and, if not, that the women be referred for HSG.

Abortion, Spontaneous↗
PubMed1980

Fetal movements registered by the pregnant woman correlated to retrospective estimations of fetal movements from cardiotocographic tracings.

After reviewing 30 cardiotocographic tracings from 15 pregnant women who directly registered fetal movements (FM) on the cardiotocographic (CT) tracings, we have found no correlation between the actual number of FM and the FM found by retrospective estimation from CT tracings. Ours is the first study to show this lack of correlation. On the contrary, we have found that by using the "retrospective" or "indirect" methods, almost 90% of the FM are overlooked. This is a very important loss of information since registration of FM seems to be a good method for surveillance of the fetus at risk. We also discuss our own methods for overcoming these problems.

Female↗