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Biomedical subjects

P Joder

Publications and source records attributed to P Joder.

7 recordsLinked to original sources
PubMed1980

Proliferation activity and bacteriostatic potential of human blood monocytes, macrophages in pleural effusions, ascites, and of alveolar macrophages.

Human blood monocytes, macrophages from pleural effusions, ascites, and alveolar macrophages obtained by bronchopulmonary lavage were investigated. The proliferative activity of these cells was determined by the 3H-thymidine labeling index in vitro (3H-TDR L.I.). The bacteriostatic capacity was measured by the potential of the cells to block DNA-synthesis of proliferating Escherichia coli after phagocytosis. In most cases 3H-TDR L.I. of blood monocytes, macrophages from pleural effusions and ascites was less than 1%. However, macrophages of some patients with neoplastic diseases exhibited 3H-TDR L.I. between 4.0--9.6%. This probably reflected the action of factors, possibly lymphokines, which stimulated macrophage proliferation. In contrast, alveolar macrophages seemed to have almost totally lost their proliferative potential. The bacteriostatic capacity of blood monocytes proved to be significantly lower than that of macrophages. This demonstrates the functional immaturity of blood monocytes. In all type of macrophages investigated the bacteriostatic power was very high. No differences could be detected either between macrophages of different sources or between macrophages of benign, inflammatory, or malignant diseases.

Ascites↗
PubMed1979

[Bronchial cytology--value of various methods for the diagnosis of primary lung neoplasms. A computation of the materials sent in to the cytological laboratory of the Institute of Pathology, Kantonspital, St. Gallen].

During the period 1973-1977 some 6100 sputum cytologies from 3000 patients were performed. All patients had suspected primary bronchogenic carcinoma. Sputum cytology was diagnostic in 547 patients (18%). A synopsis of all patients with proven lung cancer and at least one primary sputum cytology shows that this method was diagnostic in 80%. Fiberoptic bronchoscopy with its associated procedures (biopsies, brushings, washings) was the most frequently performed endoscopic method at our Department of Medicine. Fiberbronchoscopy used in combination with cytologic brushings was diagnostic in 83% of the proven cancers. Formerly, bronchial washings and bronchial secretions were obtained by means of rigid bronchoscope. This material yielded the lowest percentage (51%) of all cytological methods used at the Cantonal Hospital. The indications for use of the different diagnostic methods mentioned above and important factors which yield a high percentage of positive cytologies are discussed.

Bronchoscopy↗
PubMed1978

[Proliferative activity and bacteriostatic capacity of human alveolar macrophages (proceedings)].

Human alveolar macrophages were collected by bronchopulmonary lavage and their proliferation activity and bacteriostatic capacity determined in vitro. Compared with blood monocytes the alveolar macrophages show a higher degree of differentiation with a very high bacteriostatic capacity and no proliferation acitivity. There were no major differences between alveolar macrophages from healthy individuals, heavy smokers and patients with bronchogenic cancer.

Bronchial Neoplasms↗
PubMed1976

[Silicosis, chronic bronchitis and smoking habits].

In 333 patients suffereing from silicosis the incidence of chronic bronchitis and/or obstruction of the respiratory tract has been correlated with cigarette smoking. The incidence of chronic bronchitis and/or airway obstruction in patients who had acquired either slight or severe silicosis in Switzerland was over 50%. A positive correlation between cigarette smoking and chronic bronchitis and/or airway obstruction could be found only in younger patients with slight silicosis. Chronic bronchitis and/or airway obstruction was not more frequent in foundry-workers suffering from silicosis where they had been exposed to fumes which irritated the respiratory tract. Deformation of the respiratory tract due to silicosis has a greater bearing on the development of chronic bronchitis and airway obstruction than immoderate cigarette smoking.

Adult↗