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Biomedical subjects

P Josephsen

Publications and source records attributed to P Josephsen.

14 recordsLinked to original sources
PubMed1990

Determination of T1- and T2-relaxation times in the spleen of patients with splenomegaly.

Twenty-nine patients with known splenomegaly and seven healthy volunteers were examined. The T1 and T2 relaxation times were read out from a region of interest centrally in the spleen. Even though different mean T1 and T2 relaxation times were found between the groups, the great scatter and the considerable overlap between the groups makes the contribution of relaxation time measurements to the differential diagnosis of splenomegaly of limited value.

Diagnosis, Differential↗
PubMed1988

[Aspartame].

Explore the source record for details and available documents.

Animals↗
PubMed1985

Wegener's granulomatosis diagnosed by open lung biopsy.

A 21 year old man was diagnosed as having Wegener's granulomatosis at thoracotomy. Treatment with prednisolone and cyclophosphamide was initiated but the patient died 4 months later. Wegener's granulomatosis is a rare disease which should be considered in the differential diagnosis of pulmonary malignancies, tuberculosis and lung abscess. Early diagnosis is mandatory for a favourable outcome. Open lung biopsy is recommended, if other examinations have failed, as large representative biopsies can be obtained.

Adult↗
PubMed1980

Incidence of reamputation and death after gangrene of the lower extremity.

Since 1972 the Danish Amputation Register (DAR) has recorded major amputations in Denmark. The register is based on voluntary detailed reports from surgical and orthopaedic departments. The present investigation is based upon 2029 amputations for arteriosclerotic and diabetic gangrene with an observation period up to 4 years. The incidence of ipsilateral reamputation is high in the immediate postoperative period with 10.4% after one month, 16.5% after three months and 18.8% after six months. Later the incidence is quite low, reaching a total of 23.1% after four years. The risk of contralateral amputation is ever present with an incidence of 11.9% within one year, 17.8% after two years, 27.2% after three years, and finally 44.3% after four years. The mortality after three months is 16.3% and then tapers off to a total of 22.5% after four years. As compared with the normal population a significant over-mortality is seen during the first three months, and an equally significant under-mortality from six months onward during the observation period.

Amputation, Surgical↗