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Biomedical subjects

P K Chandra

Publications and source records attributed to P K Chandra.

6 recordsLinked to original sources

Predominance of hepatitis B virus genotype C among Karens, the 'old settlers' of Andaman and Nicobar Islands, India.

The Karens, or 'old settlers', migrated from Myanmar to Andaman and Nicobar islands 80 years ago. A high HBV exposure rate among them has been reported. A study of 34 HBsAg carriers was done to investigate the origin of HBV infection among the Karens. RFLP-based genotyping was confirmed by sequencing and phylogenetic analysis. The predominance of HBV/C1/Cs suggests that they carried HBV during their migration, retained it, and in addition, acquired HBV/D2 from the people of mainland India. The reported association of HBV genotype C with disease severity thus warrants further epidemiological investigations among them and on possible spread among neighboring settlers.

Adolescent↗

Jervell-Lange Nielsen syndrome in a family with the long QT Syndrome (LQTS).

A child with Jervell-Lange Nielsen syndrome is presented from Kolkata. Family study showed that the other family members are suffering from long QT syndrome. The child had frequent syncopal attack and very prolonged QT interval requiring left cardiac sympathetic denervation and beta-blocker therapy as patient could not afford implantable defibrillator and cardiac pacing.

Adrenergic beta-Antagonists↗

Assessment and predictability of ANB angle.

This cephalometric study consisting of thirty three orthodontic patients in the age group of 13 to 15 years was carried out to: 1. Evaluate the relationship between angle ANB and horizontal distance between jaws at the level of point A (r = 0.99); 2. Evaluate the relationship between angle ANB and Wits appraisal (r = 0.95 when mandibular plane angle is within normal limits of 32 +/- 5); 3. Predict angle ANB from Wits appraisal and vice versa (which was 90 percent correct in mesofacial type and obtained by the regression equation: angle ANB = 2.31 + 1.00 x Wits value; and 4. Evaluate the validity of angle ANB compared to other methods (angle ANB 78.5 percent in agreement with the standard followed by Wits 64.28 percent).

Adolescent↗