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Biomedical subjects

P K Puranik

Publications and source records attributed to P K Puranik.

7 recordsLinked to original sources
PubMedDate not supplied

Study of shellac glycerol esters as microencapsulating materials.

Shellac esters were prepared by heating shellac with glycerol and intermediate reaction products were withdrawn. Salicyclic acid granules were encapsulated using a 20 per cent w/v alcoholic solution of shellac and shellac esters. The coated microcapsules were evaluated for moisture absorption, flow properties, and dissolution studies. The drug release from coated granules was seen to depend upon the acid value of the esters. Results indicate that shellac esters could be better encapsulating material than shellac in sustained release formulation.

Capsules↗
PubMedDate not supplied

Prolonged release terbutaline sulphate microcapsules.

Terbutaline sulphate microcapsules were prepared by coacervation-phase separation induced by solvent evaporation technique. The cellulose acetate phthalate was employed as coating material alone and in combination with ethyl cellulose. The prepared microcapsules were evaluated for their drug content, particle size distribution (microscopic method), flow properties, bulk density and in vitro dissolution.

Capsules↗
PubMedDate not supplied

Study of abietic acid glycerol derivatives as microencapsulating materials.

Abietic acid (85 per cent pure) was extracted from rosin N Grade and further standardized. Abietic acid derivatives were prepared by heating abietic acid with glycerol and intermediate reaction products with different acid values were collected. Salicylic acid granules were encapsulated using a 10 per cent solution of abietic acid and its derivatives by standard spray pan technique. The coated microcapsules were evaluated for moisture absorption, dissolution and flow properties. The result showed that abietic acid glycerol derivatives, AaG-54 and AaG-20 had better moisture protection properties. Dissolution studies indicate that these derivatives could be used for delayed release of drugs.

Abietanes↗
PubMedDate not supplied

Microencapsulation of propranolol hydrochloride by the solvent evaporation technique.

Propranolol hydrochloride microcapsules were prepared by the coacervation-phase separation induced by solvent evaporation technique. The cellulose acetate phthalate was employed as coating material alone and in combination with ethyl cellulose. The prepared microcapsules were evaluated for their drug content, particle size distribution (microscopic method), flow properties, bulk density, in vitro dissolution and drug release kinetics.

Cellulose↗
PubMedDate not supplied

Preparation and evaluation of abietic acid microcapsules by a solvent evaporation technique.

Abietic acid was isolated from rosin N Grade (ISI) by a simple process and the product was further standardized. Sulphadiazine microcapsules were prepared by the solvent evaporation technique, using abietic acid as a wall-forming material. Discrete, spherical and free-flowing microcapsules were obtained by phase separation induced by solvent evaporation using bentonite as a solid emulsifier. The prepared microcapsules were evaluated for drug content, wall thickness, flow properties, size distribution, density and in vitro dissolution studies in gastric fluid. The effect of various process variables such as agitation speed, coat-core ratio, etc., on the micromeritic and release characteristics has been described.

Abietanes↗
PubMedDate not supplied

Microencapsulation of terbutaline sulphate by the solvent evaporation technique.

Terbutaline sulphate microcapsules were prepared by coacervation-phase separation (solvent evaporation) technique using ethyl cellulose as a coating material. Acetone, ethyl alcohol and isopropyl alcohol were employed as solvents for coating material. Microcapsules were evaluated for their drug content, particle size distribution (microscopic method), flow properties, bulk density, in vitro dissolution, drug release kinetics and surface characteristics (scanning electron microscopy).

Drug Compounding↗