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Biomedical subjects

P K Ray

Publications and source records attributed to P K Ray.

167 records · Page 10Linked to original sources
PubMedDate not supplied

Endemic fluorosis presenting as cervical cord compression.

Neurological involvement in fluorosis occurs in the advanced stage of the disease and is due to compression of the spinal cord and/or nerve roots. There are only a few reports on the role of surgical management of these cases in the medical literature. Five cases of fluorosis from the endemic areas of Uttar Pradesh, India, had associated cervical cord compression. Their mean age was 43 yr (range 35-50), and all cases were manual laborers. Three patients with blocked cervical subarachnoid space on myelography underwent laminectomy using local anesthesia. All three cases improved significantly after surgery. The usefulness of laminectomy in selected cases of cervical cord compression due to fluorosis is suggested.

Adult↗
PubMedDate not supplied

Protective effect of 6-MFA, an interferon inducer against acrylamide neurotoxicity.

Protective effect of 6-MFA, an interferon inducer and antiviral agent of fungal origin, was investigated against the neurotoxic effects induced by acrylamide in rats. Animals of 6-MFA (2.5, 5, 10 mg/100 gm, i.p.) pretreated plus acrylamide (ACR) group exhibited a reduction in development of hind limb paralysis which was 34, 25 and 20 (%) with increasing doses of 6-MFA respectively. Corpus striatal dopamine binding was significantly raised in the ACR treated rats while 6-MFA (10 mg) plus ACR group showed no significant change, in comparison to respective controls. Increased binding in the 6-MFA (2.5, 5 mg) pretreated plus ACR group was also evident. Glutathione-s-transferase (GST) activity was markedly reduced (66%) in ACR alone rats while no change was noted in rats pretreated with either dose of 6-MFA alone. However, a significant reversal was noted in animals of 6-MFA plus ACR group in a dose related manner. Conservation of glutathione levels and involvement of microglia, gamma-interferon and other lymphokines has been suggested for the observed protective effect of 6-MFA against neurotoxicity of ACR.

Acrylamides↗
PubMedDate not supplied

In vitro assay for erythropoietin.

An in vitro assay method for the quantitative estimation of erythropoietin has been developed. The principle of the method is based on the stimulation of LP catalyzed iodination of MIT by erythropoietin and the iodination reaction was found to be linearly proportional to the increasing concentration of erythropoietin of same potency or same concentration of increasing potency. This assay procedure could be utilized for clinical purposes for the estimation of erythropoietin content of biological samples, like urine, serum etc. This method is very simple, rapid, highly specific and sensitive enough to detect as little as 0.25 mU of erythropoietin.

Animals↗