Biomedical subjects

P K Sadasivan

Publications and source records attributed to P K Sadasivan.

10 recordsLinked to original sources

PubMed2006

Cardiac state diagnosis using adaptive neuro-fuzzy technique.

Analysis of heart rate has become a popular noninvasive tool for assessing the activities of the autonomic nervous system (ANS). These signals may either contain indicators of a current disease or even warnings about impending diseases. However, to manually study and pinpoint heart abnormalities in voluminous data is strenuous and time consuming. Here, an adaptive neuro-fuzzy network is used to classify heart abnormalities in 10 different cardiac states and shown to be effective. The results indicate a high level of efficacy of tools used with an accuracy level of more than 94%.

Algorithms↗

PubMed2005

Entropies for detection of epilepsy in EEG.

The electroencephalogram (EEG) is a representative signal containing information about the condition of the brain. The shape of the wave may contain useful information about the state of the brain. However, the human observer cannot directly monitor these subtle details. Besides, since bio-signals are highly subjective, the symptoms may appear at random in the time scale. Therefore, the EEG signal parameters, extracted and analyzed using computers, are highly useful in diagnostics. The aim of this work is to compare the different entropy estimators when applied to EEG data from normal and epileptic subjects. The results obtained indicate that entropy estimators can distinguish normal and epileptic EEG data with more than 95% confidence (using t-test). The classification ability of the entropy measures is tested using ANFIS classifier. The results are promising and a classification accuracy of about 90% is achieved.

Algorithms↗

PubMed2005

Characterization of EEG--a comparative study.

The Electroencephalogram (EEG) is a representative signal containing information about the condition of the brain. The shape of the wave may contain useful information about the state of the brain. However, the human observer cannot directly monitor these subtle details. Besides, since bio-signals are highly subjective, the symptoms may appear at random in the time scale. Therefore, the EEG signal parameters, extracted and analyzed using computers, are highly useful in diagnostics. Chaotic measures like correlation dimension (CD), largest Lyapunov exponent (LLE), Hurst exponent (H) and entropy are used to characterize the signal. Results indicate that these nonlinear measures are good discriminators of normal and epileptic EEG signals. These measures distinguish epileptic EEG and alcoholic from normal EEG with an accuracy of more than 90%. The dynamical behavior is less random for alcoholic and epileptic compared to normal. This indicates less of information processing in the brain due to the hyper-synchronization of the EEG. Hence, the application of nonlinear time series analysis to EEG signals offers insight into the dynamical nature and variability of the brain signals. As a pre-analysis step, the EEG data is tested for nonlinearity using surrogate data analysis and the results exhibited a significant difference in the correlation dimension measure of the actual data and the surrogate data.

Alcoholism↗

PubMed1996

ANC schemes for the enhancement of EEG signals in the presence of EOG artifacts.

One of the most important applications of adaptive systems is in noise cancellation using adaptive filters. In this paper, we propose adaptive noise cancellation schemes for the enhancement of EEG signals in the presence of EOG artifacts. The effect of two reference inputs is studied on simulated as well as recorded EEG signals and it is found that one reference input is enough to get sufficient minimization of EOG artifacts. This has been verified through correlation analysis also. We use signal to noise ratio and linear prediction spectra, along with time plots, for comparing the performance of the proposed schemes for minimizing EOG artifacts from contaminated EEG signals. Results show that the proposed schemes are very effective (especially the one which employs Newton's method) in minimizing the EOG artifacts from contaminated EEG signals.

Algorithms↗

PubMed1996

Detection of seizure activity in EEG by an artificial neural network: a preliminary study.

Neural networks, inspired by the organizational principles of the human brain, have recently been used in various fields of application such as pattern recognition, identification, classification, speech, vision, signal processing, and control systems. In this study, a two-layered neural network has been trained for the recognition of temporal patterns of the electroencephalogram (EEG). This network is called a Learning Vector Quantization (LVQ) neural network since it learns the characteristics of the signal presented to it as a vector. The first layer is a competitive layer which learns to classify the input vectors. The second, linear, layer transforms the output of the competitive layer to target classes defined by the user. We have tested and evaluated the LVQ network. The network successfully detects epileptiform discharges (EDs) when trained using EEG records scored by a neurologist. Epochs of EEG containing EDs from one subject have been used for training the network, and EEGs of other subjects have been used for testing the network. The results demonstrate that the LVQ detector can generalize the learning to previously "unseen" records of subjects. This study shows that the LVQ network offers a practical solution for ED detection which is easily adjusted to an individual neurologist's style and is as sensitive and specific as an expert visual analysis.

Adolescent↗

PubMed1996

The nature of dominant Lyapunov exponent and attractor dimension curves of EEG in sleep.

The dynamical behaviour of the brain is currently being viewed from the perspective of nonlinear dynamics. There are several reports of low dimensional chaotic activity in various states of human behaviour. The time evolution of chaotic systems exhibit many transitional states and brain is known to undergo a number of transitions in sleep. It evolves from random looking states to almost periodic states with an increase in the depth of sleep. There occurs intermittent random-like behaviour in REM (rapid eye movement) sleep. In this paper, we examine the transitional processes of brain activity in sleep from the patterns of attractor dimension (D2) and its corresponding dominant Lyapunov exponent (lambda 1) curves of EEG signals. Results indicate the occurrence of different degrees of chaoticity in the transitional states that may be related to various sleep stages. The chaotic parameter curves yield an objective measure of the neurodynamics of sleep comparable to an hypnogram. The parallelism of D2 and lambda 1 curves implies the validity of Kaplan-Yorke conjecture for EEG. It is suggested that the nonlinear dynamical measures of EEG may yield information about the nature of underlying neural processes of brain in sleep.

Adolescent↗

PubMed1995

Use of finite wordlength FIR digital filter structures with improved magnitude and phase characteristics for reduction of muscle noise in EEG signals.

One of the main disturbances in EEG signals is EMG artefacts generated by muscle movements. In the paper, the use of a linear phase FIR digital low-pass filter with finite wordlength precision coefficients is proposed, designed using the compensation procedure, to minimise EMG artefacts in contaminated EEG signals. To make the filtering more effective, different structures are used, i.e. cascading, twicing and sharpening (apart from simple low-pass filtering) of the designed FIR filter. Modifications are proposed to twicing and sharpening structures to regain the linear phase characteristics that are lost in conventional twicing and sharpening operations. The efficacy of all these transformed filters in minimising EMG artefacts is studied, using SNR improvements as a performance measure for simulated signals. Time plots of the signals are also compared. Studies show that the modified sharpening structure is superior in performance to all other proposed methods. These algorithms have also been applied to real or recorded EMG-contaminated EEG signal. Comparison of time plots, and also the output SNR, show that the proposed modified sharpened structure works better in minimising EMG artefacts compared with other methods considered.

Artifacts↗

PubMed1995

Patterns of attractor dimensions of sleep EEG.

Low dimensional chaos is a property of many physiological oscillatory systems including the brain. Time series of sleep EEG records have been analyzed in the framework of recent developments in nonlinear dynamics. One of the characteristics of a chaotic time series is its attractor dimension. The running attractor dimension of a chaotic time series may reflect changes in states more accurately than manually scored records. In the present study the attractor dimensions of consecutive EEG segments of five sleep records were analyzed. The block of the EEG segment (window) was shifted by various lengths along the entire sleep data of each subject thus producing a running attractor dimension curve for each record. The attractor dimension values for different sleep stages were significantly different. The pattern of the running attractor dimension closely matched the scored hypnograms in these five sleep records.

Adolescent↗

PubMed1994

Minimization of EOG artefacts from corrupted EEG signals using a neural network approach.

In this paper, we propose a neural network (NN) approach to the enhancement of EEG signals in the presence of EOG artefacts. We recast the EEG enhancement problem into the optimization framework by developing an appropriate cost function. The cost function is nothing but the energy in the enhanced EEG signal obtained through a nonlinear filter formulation, unlike the conventionally-used linear filter formulation. The minimization property of feedback-type neural networks is exploited to solve this problem. An analysis has been performed to characterize the stationary points of the suggested energy function. The hardware set-up of the developed neural network has also been derived. The optimum nonlinear filter coefficients obtained from this minimization algorithm are used to estimate the EOG artefact which is then subtracted from the corrupted EEG signal, sample by sample, to get the artefact minimized signal. The time plots as the LP spectrum show that the proposed method is very effective. Thus the power and efficacy of the NN approach have been exploited for the purpose of minimizing EOG artefacts from corrupted EEG signals.

Algorithms↗

PubMed1994

A non-linear estimation model for adaptive minimization of EOG artefacts from EEG signals.

In this paper, we propose an adaptive noise cancellation scheme in a novel way for the minimization of electrooculogram (EOG) artefacts from corrupted EEG signals. This method is based on the fact that the transfer function of the biological neuron can be modeled as a sigmoid non-linearity. Comparison of the time plots and the smoothed linear prediction spectra show that the proposed method effectively minimizes the EOG artefacts from corrupted EEG signals. We have also studied the performance of the above scheme for different values of filter order (P) and the convergence factor (mu). Normalised Mean Squared Error (NMSE) has been used as the measure for comparison. The study shows that the NMSE decreases with increase in P and mu (but saturates after certain values of the parameters), thereby implying a better EOG minimization from EEG signals. It is also observed that the EOG minimization scheme with two EOG reference inputs works better than that with one reference input.

Algorithms↗